Diego Gomez-Nicola
Overview
Explore the profile of Diego Gomez-Nicola including associated specialties, affiliations and a list of published articles.
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63
Citations
3265
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Recent Articles
1.
Heneka M, van der Flier W, Jessen F, Hoozemanns J, Thal D, Boche D, et al.
Nat Rev Immunol
. 2024 Dec;
PMID: 39653749
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines...
2.
Fancy N, Smith A, Caramello A, Tsartsalis S, Davey K, Muirhead R, et al.
Acta Neuropathol
. 2024 May;
147(1):78.
PMID: 38695952
Aging is associated with cell senescence and is the major risk factor for AD. We characterized premature cell senescence in postmortem brains from non-diseased controls (NDC) and donors with Alzheimer's...
3.
Barry-Carroll L, Gomez-Nicola D
Nat Rev Neurosci
. 2024 Apr;
25(6):414-427.
PMID: 38658739
Microglia constitute the largest population of parenchymal macrophages in the brain and are considered a unique subset of central nervous system glial cells owing to their extra-embryonic origins in the...
4.
Guerrero-Carrasco M, Targett I, Olmos-Alonso A, Vargas-Caballero M, Gomez-Nicola D
Glia
. 2024 Apr;
72(7):1340-1355.
PMID: 38597386
Several in vivo studies have shown that systemic inflammation, mimicked by LPS, triggers an inflammatory response in the CNS, driven by microglia, characterized by an increase in inflammatory cytokines and...
5.
Askew K, Beverley J, Sigfridsson E, Szymkowiak S, Emelianova K, Dando O, et al.
Glia
. 2023 Nov;
72(2):375-395.
PMID: 37909242
White matter abnormalities, related to poor cerebral perfusion, are a core feature of small vessel cerebrovascular disease, and critical determinants of vascular cognitive impairment and dementia. Despite this importance there...
6.
Barry-Carroll L, Greulich P, Marshall A, Riecken K, Fehse B, Askew K, et al.
Cell Rep
. 2023 Apr;
42(5):112425.
PMID: 37099424
Microglia arise from the yolk sac and enter the brain during early embryogenesis. Upon entry, microglia undergo in situ proliferation and eventually colonize the entire brain by the third postnatal...
7.
Vicente-Rodriguez M, Mancuso R, Peris-Yague A, Simmons C, Gomez-Nicola D, Perry V, et al.
J Neuroinflammation
. 2023 Apr;
20(1):92.
PMID: 37032328
Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or a secondary outcome. For that reason, either as diagnostic tools or to monitor progression and/or...
8.
Paolicelli R, Sierra A, Stevens B, Tremblay M, Aguzzi A, Ajami B, et al.
Neuron
. 2022 Nov;
110(21):3458-3483.
PMID: 36327895
Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification...
9.
Menassa D, Muntslag T, Martin-Estebane M, Barry-Carroll L, Chapman M, Adorjan I, et al.
Dev Cell
. 2022 Aug;
57(17):2127-2139.e6.
PMID: 35977545
Microglia, the brain's resident macrophages, shape neural development and are key neuroimmune hubs in the pathological signatures of neurodevelopmental disorders. Despite the importance of microglia, their development has not been...
10.
Hu Y, Fryatt G, Ghorbani M, Obst J, Menassa D, Martin-Estebane M, et al.
Cell Rep
. 2021 Jun;
35(10):109228.
PMID: 34107254
The sustained proliferation of microglia is a key hallmark of Alzheimer's disease (AD), accelerating its progression. Here, we aim to understand the long-term impact of the early and prolonged microglial...