Dick van der Helm
Overview
Explore the profile of Dick van der Helm including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
196
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Recent Articles
1.
Piyamongkol S, Ma Y, Kong X, Liu Z, Aytemir M, van der Helm D, et al.
Chemistry
. 2010 Apr;
16(21):6374-81.
PMID: 20397153
The synthesis and physicochemical properties of a range of 2- and 6-amido-3-hydroxypyridin-4-ones are described. All the amido-substituted 3-hydroxypyridin-4-ones have lower pK(a) values than 1,2-dimethyl-3-hydroxypyridin-4-one (deferiprone). This is due to the...
2.
Chakraborty R, Storey E, van der Helm D
Biometals
. 2006 Dec;
20(3-4):263-74.
PMID: 17186377
Iron is an essential nutrient for all microorganisms with a few exceptions. Microorganisms use a variety of systems to acquire iron from the surrounding environment. One such system includes production...
3.
Chakraborty R, Lemke E, Cao Z, Klebba P, van der Helm D
Biometals
. 2003 Jun;
16(4):507-18.
PMID: 12779236
Many gram-negative bacteria produce and excrete siderophores, which complex iron with high affinity in the environment. The ferric siderophore complexes are transported across the outer membrane by receptor proteins. This...
4.
Ferguson A, Chakraborty R, Smith B, Esser L, van der Helm D, Deisenhofer J
Science
. 2002 Mar;
295(5560):1715-9.
PMID: 11872840
Siderophore-mediated acquisition systems facilitate iron uptake. We present the crystallographic structure of the integral outer membrane receptor FecA from Escherichia coli with and without ferric citrate at 2.5 and 2.0...
5.
Abbas S, Hossain M, van der Helm D, Schmitz F, Laney M, Cabuslay R, et al.
J Org Chem
. 1996 Dec;
61(25):9072.
PMID: 11667906
No abstract available.
6.
Abas S, Hossain M, van der Helm D, Schmitz F, Laney M, Cabuslay R, et al.
J Org Chem
. 1996 Apr;
61(8):2709-2712.
PMID: 11667102
Two new alkaloids, polycarpine (1) and N,N-didesmethylgrossularine-1 (4), have been isolated from extracts of the ascidian Polycarpa aurata collected in Chuuk, Federated States of Micronesia. Three degradation products of 1...