Diane Hoffman-Kim
Overview
Explore the profile of Diane Hoffman-Kim including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
656
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Recent Articles
1.
McLaughlin R, Top I, Laguna A, Hernandez C, Katz H, Livi L, et al.
In Vitro Model
. 2025 Jan;
2(1-2):25-41.
PMID: 39872876
Purpose: Ischemic brain injury occurs when there is reduced or complete disruption of blood flow to a brain region, such as in stroke or severe traumatic brain injury. Even short...
2.
Zein-Sabatto A, St Angelo K, Madnick S, Hoffman-Kim D, Morgan J, Lee J
Sci Rep
. 2025 Jan;
15(1):3090.
PMID: 39856149
Cell viability assays are an integral component of toxicology and high-throughput drug screening studies; however, many assays rely on a single biomarker of cell death which provides an incomplete assessment...
3.
Gonzalez-Cruz R, Wan Y, Burgess A, Calvao D, Renken W, Vecchio F, et al.
PLoS One
. 2024 Aug;
19(8):e0295086.
PMID: 39159236
Sustained compressive injury (SCI) in the brain is observed in numerous injury and pathological scenarios, including tumors, ischemic stroke, and traumatic brain injury-related tissue swelling. Sustained compressive injury is characterized...
4.
Wan Y, Gonzalez-Cruz R, Hoffman-Kim D, Kesari H
Biomech Model Mechanobiol
. 2024 Jul;
23(4):1179-1196.
PMID: 38970736
Brain injuries resulting from mechanical trauma represent an ongoing global public health issue. Several in vitro and in vivo models for traumatic brain injury (TBI) continue to be developed for...
5.
Sevetson J, Theyel B, Hoffman-Kim D
Lab Chip
. 2021 Nov;
21(23):4586-4595.
PMID: 34734621
Three-dimensional brain cultures can facilitate the study of central nervous system function and disease, and one of the most important components that they present is neuronal activity on a network...
6.
Lizarraga S, Ma L, Maguire A, van Dyck L, Wu Q, Ouyang Q, et al.
Sci Transl Med
. 2021 Feb;
13(580).
PMID: 33568516
Christianson syndrome (CS), an X-linked neurological disorder characterized by postnatal attenuation of brain growth (postnatal microcephaly), is caused by mutations in , the gene encoding endosomal Na/H exchanger 6 (NHE6)....
7.
Evans E, Brady S, Tripathi A, Hoffman-Kim D
Biomater Res
. 2018 May;
22:14.
PMID: 29780613
Background: Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect. Although several groups have studied directed migration of Schwann cells in...
8.
Boutin M, Kramer L, Livi L, Brown T, Moore C, Hoffman-Kim D
J Neurosci Methods
. 2017 Feb;
299:55-63.
PMID: 28143748
Background: In vitro three-dimensional neural spheroid models have an in vivo-like cell density, and have the potential to reduce animal usage and increase experimental throughput. The aim of this study...
9.
Sadick J, Boutin M, Hoffman-Kim D, Darling E
Sci Rep
. 2016 Sep;
6:33999.
PMID: 27666089
Cellular heterogeneity is inherent in most human tissues, making the investigation of specific cell types challenging. Here, we describe a novel, fixation/intracellular target-based sorting and protein extraction method to provide...
10.
Lopez-Fagundo C, Livi L, Ramchal T, Darling E, Hoffman-Kim D
Acta Biomater
. 2016 May;
39:55-64.
PMID: 27142253
Unlabelled: Successful realization of the enormous potential of pluripotent stem cells in regenerative medicine demands the development of well-defined culture conditions. Maintenance of embryonic stem cells (ESCs) typically requires co-culture...