Diana G Eng
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Explore the profile of Diana G Eng including associated specialties, affiliations and a list of published articles.
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28
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543
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Recent Articles
1.
Ali A, Liu Z, Ye K, Guan Y, Chen S, Liu T, et al.
bioRxiv
. 2024 Nov;
PMID: 39554089
Renal glomeruli have traditionally been studied by micrometer-scale optical microscopy to interrogate overall physiology or molecular distributions and by nanoscale electron microscopy to interrogate the ultrastructure of thin sections. While...
2.
McKinzie S, Kaverina N, Schweickart R, Chaney C, Eng D, Pereira B, et al.
Am J Physiol Renal Physiol
. 2024 Feb;
326(4):F644-F660.
PMID: 38420674
Patients with hypertension or obesity can develop glomerular dysfunction characterized by injury and depletion of podocytes. To better understand the molecular processes involved, young mice were treated with either deoxycorticosterone...
3.
Pereira B, Zeng Y, Maggiore J, Schweickart R, Eng D, Kaverina N, et al.
Am J Physiol Renal Physiol
. 2023 Oct;
326(1):F120-F134.
PMID: 37855038
As life expectancy continues to rise, age-related diseases are becoming more prevalent. For example, proteinuric glomerular diseases typified by podocyte injury have worse outcomes in the elderly compared with young...
4.
Kaverina N, Schweickart R, Chan G, Maggiore J, Eng D, Zeng Y, et al.
Aging (Albany NY)
. 2023 Jul;
15(14):6658-6689.
PMID: 37487005
The decrease in the podocyte's lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function. The ability to halt and even reverse...
5.
Pippin J, Kaverina N, Wang Y, Eng D, Zeng Y, Tran U, et al.
J Clin Invest
. 2022 Aug;
132(16).
PMID: 35968783
With an aging population, kidney health becomes an important medical and socioeconomic factor. Kidney aging mechanisms are not well understood. We previously showed that podocytes isolated from aged mice exhibit...
6.
Kaverina N, Eng D, Miner J, Pippin J, Shankland S
Aging (Albany NY)
. 2020 Aug;
12(17):17601-17624.
PMID: 32858527
Healthy aging is typified by a progressive and absolute loss of podocytes over the lifespan of animals and humans. To test the hypothesis that a subset of glomerular parietal epithelial...
7.
Liu G, Pippin J, Eng D, Lv S, Shankland S, Pun S
Physiol Rep
. 2020 Aug;
8(15):e14545.
PMID: 32786069
Loss and dysfunction of glomerular podocytes result in increased macromolecule permeability through the glomerular filtration barrier and nephrotic syndrome. Current therapies can induce and maintain disease remission, but cause serious...
8.
Hamatani H, Eng D, Hiromura K, Pippin J, Shankland S
Physiol Rep
. 2020 Jun;
8(12):e14487.
PMID: 32597007
CD44 contributes to the activation of glomerular parietal epithelial cells (PECs). Although CD44 expression is higher in PECs of healthy aged mice, the biological role of CD44 in PECs in...
9.
Wang Y, Eng D, Kaverina N, Loretz C, Koirala A, Akilesh S, et al.
Kidney Int
. 2020 Jun;
98(5):1160-1173.
PMID: 32592814
Glomerular podocytes undergo structural and functional changes with advanced age, that increase susceptibility of aging kidneys to worse outcomes following superimposed glomerular diseases. To delineate transcriptional changes in podocytes in...
10.
Chan G, Eng D, Miner J, Alpers C, Hudkins K, Chang A, et al.
Am J Physiol Renal Physiol
. 2019 Oct;
317(6):F1680-F1694.
PMID: 31630546
In healthy glomeruli, parietal epithelial cell (PEC)-derived extracellular matrix (ECM) proteins include laminin-β, perlecan, and collagen type IV-α and podocyte-specific ECM proteins include laminin-β, agrin, and collagen type IV-α. This...