Dhaarmini Rajshankar
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Explore the profile of Dhaarmini Rajshankar including associated specialties, affiliations and a list of published articles.
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11
Citations
102
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Recent Articles
1.
Aschner Y, Nelson M, Brenner M, Roybal H, Beke K, Meador C, et al.
Am J Physiol Lung Cell Mol Physiol
. 2020 Jun;
319(2):L294-L311.
PMID: 32491951
Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal, fibrosing lung disease for which treatment remains suboptimal. Fibrogenic cytokines, including transforming growth factor-β (TGF-β), are central to its pathogenesis. Protein...
2.
Rajshankar D, Wang B, Worndl E, Menezes S, Wang Y, McCulloch C
J Cell Physiol
. 2019 Sep;
235(3):3096-3111.
PMID: 31556111
Focal adhesion kinase (FAK) is critical for collagen expression but its regulation of collagen remodeling is not defined. We examined the role of FAK in the degradation and reorganization of...
3.
Rajshankar D, Wang Y, McCulloch C
FASEB J
. 2016 Nov;
31(3):937-953.
PMID: 27881487
Focal adhesion kinase (FAK) is critical in adhesion-dependent signaling, but its role in osteogenesis is ill defined. We deleted in fibroblasts and osteoblasts in mice bred with those expressing Cre-recombinase...
4.
Bozavikov P, Rajshankar D, Lee W, McCulloch C
Exp Cell Res
. 2014 Jul;
328(1):172-185.
PMID: 24995996
The application of nanotechnology for drug targeting underlines the importance of controlling the kinetics and cellular sites of delivery for optimal therapeutic outcomes. Here we examined the effect of particle...
5.
Wang Q, Wang Y, Fritz D, Rajshankar D, Downey G, McCulloch C
J Biol Chem
. 2014 May;
289(26):18427-41.
PMID: 24821720
Interleukin-1 (IL-1) signaling in fibroblasts is mediated through focal adhesions, organelles that are enriched with adaptor and cytoskeletal proteins that regulate signal transduction. We examined interactions of the focal adhesion...
6.
Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen
Staudinger L, Spano S, Lee W, Coelho N, Rajshankar D, Bendeck M, et al.
Biol Open
. 2013 Nov;
2(11):1148-59.
PMID: 24244851
Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the...
7.
Rajshankar D, Sima C, Wang Q, Goldberg S, Kazembe M, Wang Y, et al.
PLoS One
. 2013 Aug;
8(8):e70659.
PMID: 23940616
IL-1β contributes to connective tissue destruction in part by up-regulating stromelysin-1 (MMP-3), which in fibroblasts is a focal adhesion-dependent process. Protein tyrosine phosphatase-α (PTPα) is enriched in and regulates the...
8.
Wang Y, Wang Q, Arora P, Rajshankar D, McCulloch C
Periodontol 2000
. 2013 Aug;
63(1):48-58.
PMID: 23931053
Adhesion molecules expressed by periodontal connective tissue cells are involved in cell migration, matrix remodeling and inflammatory responses to infection. Currently, the processes by which the biologic activity of these...
9.
Rajshankar D, Downey G, McCulloch C
FASEB J
. 2012 Jul;
26(11):4429-44.
PMID: 22829527
IL-1β is a prominent proinflammatory cytokine that mediates degradation of extracellular matrix proteins through increased expression of matrix metalloproteinases, which involves a signaling pathway in adherent cells that is restricted...
10.
Wang Q, Rajshankar D, Laschinger C, Talior-Volodarsky I, Wang Y, Downey G, et al.
J Biol Chem
. 2010 May;
285(29):22308-17.
PMID: 20472558
Interleukin-1 (IL-1) induces extracellular matrix degradation as a result of increased expression of matrix metalloproteinases (MMPs). We examined adhesion-restricted signaling pathways that enable IL-1-induced MMP release in human gingival and...