Derrick E Rancourt
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Explore the profile of Derrick E Rancourt including associated specialties, affiliations and a list of published articles.
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85
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1586
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Recent Articles
1.
Borys B, Dang T, Worden H, Larijani L, Corpuz J, Abraham B, et al.
Stem Cell Res Ther
. 2024 Jul;
15(1):232.
PMID: 39075528
Background: While pluripotent stem cell (PSC) therapies move toward clinical and commercial applications at a rapid rate, manufacturing reproducibility and robustness are notable bottlenecks in regulatory approval. Therapeutic applications of...
2.
Nath S, Babaei-Abraki S, Meng G, Heale K, Hsu C, Rancourt D
Commun Biol
. 2024 Feb;
7(1):190.
PMID: 38365890
Enzymatic dissociation of human pluripotent stem cells (hPSCs) into single cells during routine passage leads to massive cell death. Although the Rho-associated protein kinase inhibitor, Y-27632 can enhance hPSC survival...
3.
Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury
Ferrie L, Premnath P, Olsen A, Larijani L, Besler B, Rancourt D, et al.
Sci Rep
. 2023 Jun;
13(1):9378.
PMID: 37296277
Promoting bone healing including fracture non-unions are promising targets for bone tissue engineering due to the limited success of current clinical treatment methods. There has been significant research on the...
4.
Heale K, Nath S, Rancourt D
Curr Protoc
. 2021 Sep;
1(9):e230.
PMID: 34491629
Progress in extracellular vesicle (EV) research over the past two decades has generated significant interest in using EVs in the biomedical field. Exosomes are a subgroup of EVs that comprise...
5.
Helmi S, Rohani L, Zaher A, El Hawary Y, Rancourt D
Int J Mol Sci
. 2021 Jun;
22(10).
PMID: 34069142
Bone healing is a complex, well-organized process. Multiple factors regulate this process, including growth factors, hormones, cytokines, mechanical stimulation, and aging. One of the most important signaling pathways that affect...
6.
Nath S, Day B, Harper L, Yee J, Hsu C, Larijani L, et al.
Stem Cells
. 2021 Apr;
39(9):1166-1177.
PMID: 33837584
The expansion of pluripotent stem cells (PSCs) as aggregates in stirred suspension bioreactors is garnering attention as an alternative to adherent culture. However, the hydrodynamic environment in the bioreactor can...
7.
Borys B, Dang T, So T, Rohani L, Revay T, Walsh T, et al.
Stem Cell Res Ther
. 2021 Jan;
12(1):55.
PMID: 33436078
Background: Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potential, however, has...
8.
Nath S, Harper L, Rancourt D
Front Bioeng Biotechnol
. 2020 Dec;
8:599674.
PMID: 33324625
Cell-based therapy (CBT) is attracting much attention to treat incurable diseases. In recent years, several clinical trials have been conducted using human pluripotent stem cells (hPSCs), and other potential therapeutic...
9.
Waldner D, Ito K, Chen L, Nguyen L, Chow R, Lee A, et al.
Transl Vis Sci Technol
. 2020 Oct;
9(11):19.
PMID: 33117610
Purpose: Congenital stationary night blindness 2A (CSNB2A) is a genetic retinal disorder characterized by poor visual acuity, nystagmus, strabismus, and other signs of retinal dysfunction resulting from mutations in the...
10.
Rohani L, Borys B, Razian G, Naghsh P, Liu S, Johnson A, et al.
Commun Biol
. 2020 Sep;
3(1):492.
PMID: 32895477
Due to their ability to standardize key physiological parameters, stirred suspension bioreactors can potentially scale the production of quality-controlled pluripotent stem cells (PSCs) for cell therapy application. Because of differences...