Derek van der Kooy
Overview
Explore the profile of Derek van der Kooy including associated specialties, affiliations and a list of published articles.
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144
Citations
5016
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Recent Articles
11.
Grise K, Coles B, Bautista N, van der Kooy D
Stem Cell Res Ther
. 2021 Oct;
12(1):560.
PMID: 34717744
Background: The adult mammalian retina does not have the capacity to regenerate cells lost due to damage or disease. Therefore, retinal injuries and blinding diseases result in irreversible vision loss....
12.
Coles B, Labib M, Poudineh M, Innes B, Belair-Hickey J, Gomis S, et al.
Lab Chip
. 2021 Oct;
21(22):4464-4476.
PMID: 34651637
Loss of photoreceptors due to retinal degeneration is a major cause of untreatable visual impairment and blindness. Cell replacement therapy, using retinal stem cell (RSC)-derived photoreceptors, holds promise for reconstituting...
13.
Baakdhah T, Coles B, van der Kooy D
iScience
. 2021 Jun;
24(6):102574.
PMID: 34151227
Retinal stem cells (RSCs) are rare pigmented cells found in the pigmented ciliary layer of the mammalian retina. Studies show that RSCs can replicate to maintain the stem cell pool...
14.
Baker A, Cui H, Ballios B, Ing S, Yan P, Wolfer J, et al.
Biomaterials
. 2021 Mar;
271:120750.
PMID: 33725584
Vitreous substitutes are clinically used to maintain retinal apposition and preserve retinal function; yet the most used substitutes are gases and oils which have disadvantages including strict face-down positioning post-surgery...
15.
Grise K, Bautista N, Jacques K, Coles B, van der Kooy D
Stem Cell Res Ther
. 2021 Jan;
12(1):83.
PMID: 33494791
Background: Adult mammalian retinal stem cells (RSCs) readily proliferate, self-renew, and generate progeny that differentiate into all retinal cell types in vitro. RSC-derived progeny can be induced to differentiate into...
16.
Adams K, Mahmud N, Green-Holland M, Vonderwalde I, Umebayashi D, Sachewsky N, et al.
Eur J Neurosci
. 2020 Oct;
53(4):1334-1349.
PMID: 33010080
Neonatal stroke is a leading cause of long-term disability and currently available rehabilitation treatments are insufficient to promote recovery. Activating neural precursor cells (NPCs) in adult rodents, in combination with...
17.
Deveale B, van der Kooy D
Neuron
. 2020 Sep;
107(6):994-996.
PMID: 32971001
In this issue, Laukoter et al., 2020 report that parent-of-origin-dependent expression is homogeneous across distinct cortical cell types and within individual populations. Conversely, they observe preferential sensitivity of astrocytes to...
18.
Mitrousis N, Hacibekiroglu S, Ho M, Sauve Y, Nagy A, van der Kooy D, et al.
Biomaterials
. 2020 Aug;
257:120233.
PMID: 32791386
We demonstrate a novel approach to reverse advanced stages of blindness using hydrogel-mediated delivery of retinal pigmented epithelium (RPE) and photoreceptors directly to the degenerated retina of blind mice. With...
19.
Ahuja C, Mothe A, Khazaei M, Badhiwala J, Gilbert E, van der Kooy D, et al.
Stem Cells Transl Med
. 2020 Jul;
9(12):1509-1530.
PMID: 32691994
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial costs for millions of individuals and families worldwide. Rapid delivery of specialized medical and surgical care has reduced...
20.
Yee M, Maal-Bared G, Ting-A-Kee R, Chwalek M, MacKay-Clackett I, Bergamini M, et al.
Eur J Neurosci
. 2020 Mar;
52(3):3074-3086.
PMID: 32150654
Caffeine, the most commonly consumed psychoactive drug in the world, is readily available in dietary sources, including soft drinks, chocolate, tea and coffee. However, little is known about the neural...