Derek Sieburth
Overview
Explore the profile of Derek Sieburth including associated specialties, affiliations and a list of published articles.
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26
Citations
1005
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Recent Articles
1.
Jia Q, Young D, Zhang Q, Sieburth D
Elife
. 2024 Dec;
13.
PMID: 39636673
The gut-brain axis mediates bidirectional signaling between the intestine and the nervous system and is critical for organism-wide homeostasis. Here, we report the identification of a peptidergic endocrine circuit in...
2.
Jia Q, Young D, Zhang Q, Sieburth D
bioRxiv
. 2024 Sep;
PMID: 39345448
The gut-brain axis mediates bidirectional signaling between the intestine and the nervous system and is critical for organism-wide homeostasis. Here we report the identification of a peptidergic endocrine circuit in...
3.
Choi U, Hu M, Zhang Q, Sieburth D
Nat Commun
. 2023 Jul;
14(1):4218.
PMID: 37452027
FMRFamides are evolutionarily conserved neuropeptides that play critical roles in behavior, energy balance, and reproduction. Here, we show that FMRFamide signaling from the nervous system is critical for the rhythmic...
4.
Choi U, Wang H, Hu M, Kim S, Sieburth D
Proc Natl Acad Sci U S A
. 2021 May;
118(20).
PMID: 33972428
Electrical synapses are specialized structures that mediate the flow of electrical currents between neurons and have well known roles in synchronizing the activities of neuronal populations, both by mediating the...
5.
Jia Q, Sieburth D
Nat Commun
. 2021 Apr;
12(1):2304.
PMID: 33863916
Mitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, but a role for mitochondrial-produced ROS in regulating neurosecretion has not been described. Here we...
6.
7.
Kim S, Sieburth D
Genetics
. 2019 Dec;
214(2):409-418.
PMID: 31801834
The mitochondrial unfolded protein response (UPR) is an evolutionarily conserved adaptive response that functions to maintain mitochondrial homeostasis following mitochondrial damage. In , the nervous system plays a central role...
8.
Kim S, Sieburth D
Genetics
. 2019 Feb;
211(4):1283-1295.
PMID: 30782598
The transcription factor Nrf2 plays a critical role in the organism-wide regulation of the antioxidant stress response. The Nrf2 homolog SKN-1 functions in the intestinal cells nonautonomously to negatively regulate...
9.
Kim S, Sieburth D
Cell Rep
. 2018 Sep;
24(11):2932-2945.e4.
PMID: 30208318
The mitochondrial unfolded protein response (UPR) is critical for maintaining mitochondrial protein homeostasis in response to mitochondrial stress, but early steps in UPR activation are not well understood. Here, we...
10.
Kim S, Sieburth D
J Neurosci
. 2018 Aug;
38(38):8160-8176.
PMID: 30082417
The Nrf2 antioxidant transcription factor promotes redox homeostasis in part through reciprocal signaling between neurons and neighboring cells, but the signals involved in intertissue signaling in response to Nrf2 activation...