Derek R Moen
Overview
Explore the profile of Derek R Moen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
4
Citations
37
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Zhang X, Gui L, Li S, Nandi P, Columbres R, Wong D, et al.
Biochem J
. 2021 Aug;
478(17):3185-3204.
PMID: 34405853
p97 protein is a highly conserved, abundant, functionally diverse, structurally dynamic homohexameric AAA enzyme-containing N, D1, and D2 domains. A truncated p97 protein containing the N and D1 domains and...
2.
Wang F, Moen D, Sauni C, Kan S, Li S, Le S, et al.
Mol Pharm
. 2020 Dec;
18(1):214-227.
PMID: 33320673
There is currently no cure or effective treatment available for mucopolysaccharidosis type IIID (MPS IIID, Sanfilippo syndrome type D), a lysosomal storage disorder (LSD) caused by the deficiency of α--acetylglucosamine-6-sulfatase...
3.
Gui L, Zhang X, Li K, Frankowski K, Li S, Wong D, et al.
ChemMedChem
. 2016 Apr;
11(9):953-7.
PMID: 27043824
We previously found that the p97 cofactor, p47, significantly decreased the potency of some ATP-competitive p97 inhibitors such as ML240 [2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine] and ML241 [2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8 tetrahydroquinazolin-4-amine]. In this study, we aimed...
4.
Fang C, Gui L, Zhang X, Moen D, Li K, Frankowski K, et al.
ChemMedChem
. 2014 Nov;
10(1):52-6.
PMID: 25377500
We previously found that p97 ATPase inhibitors 2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine (ML240) and 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine (ML241) specifically target the D2 domain of wild-type p97. In addition, one of the major p97 cofactors, p47, decreases...