Derek N Woolfson
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Explore the profile of Derek N Woolfson including associated specialties, affiliations and a list of published articles.
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169
Citations
4059
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Recent Articles
1.
Caroprese V, Tekin C, Cencen V, Mosayebi M, Asmari N, Liverpool T, et al.
Nat Chem
. 2025 Feb;
17(3):325-333.
PMID: 39948282
Supramolecular networks are abundantly present in nature and, like crystalline materials, often develop from an initial nucleation site, followed by growth based on directional interactions between components. Traditionally, the binding...
2.
Petrenas R, Hawkins O, Jones J, Scott D, Fletcher J, Obst U, et al.
J Am Chem Soc
. 2025 Jan;
147(4):3796-3803.
PMID: 39813445
protein design has advanced such that many peptide assemblies and protein structures can be generated predictably and quickly. The drive now is to bring functions to these structures, for example,...
3.
Kurgan K, Martin F, Dawson W, Brunnock T, Orr-Ewing A, Woolfson D
Chem Sci
. 2024 Dec;
16(4):1826-1836.
PMID: 39720134
protein design is delivering new peptide and protein structures at a rapid pace. Many of these synthetic polypeptides form well-defined and hyperthermal-stable structures. Generally, however, less is known about the...
4.
Woolfson D, Colwell L, Chen Z, Vorobieva A, Polizzi N, Stein A, et al.
Cell Syst
. 2024 Nov;
15(11):994-999.
PMID: 39571532
No abstract available.
5.
Wu M, Marchando P, Meyer K, Tang Z, Woolfson D, Weiner O
bioRxiv
. 2024 Jul;
PMID: 39026726
Cells generate a wide range of actin-based membrane protrusions for various cell behaviors. These protrusions are organized by different actin nucleation promoting factors. For example, N-WASP controls finger-like filopodia, whereas...
6.
Cawood E, Baker E, Edwards T, Woolfson D, Karamanos T, Wilson A
Chem Sci
. 2024 Jul;
15(26):10237-10245.
PMID: 38966365
A significant challenge in chemical biology is to understand and modulate protein-protein interactions (PPIs). Given that many PPIs involve a folded protein domain and a peptide sequence that is intrinsically...
7.
Albanese K, Petrenas R, Pirro F, Naudin E, Borucu U, Dawson W, et al.
Nat Chem Biol
. 2024 Jun;
20(8):991-999.
PMID: 38902458
Computational protein design is advancing rapidly. Here we describe efficient routes starting from validated parallel and antiparallel peptide assemblies to design two families of α-helical barrel proteins with central channels...
8.
Cross J, Dawson W, Shukla S, Weijman J, Mantell J, Dodding M, et al.
Nat Chem Biol
. 2024 Jun;
20(7):916-923.
PMID: 38849529
Many enzymes are allosterically regulated via conformational change; however, our ability to manipulate these structural changes and control function is limited. Here we install a conformational switch for allosteric activation...
9.
Hilditch A, Romanyuk A, Hodgson L, Mantell J, Neal C, Verkade P, et al.
J Am Chem Soc
. 2024 Apr;
146(15):10240-10245.
PMID: 38578222
Cellular compartments formed by biomolecular condensation are widespread features of cell biology. These organelle-like assemblies compartmentalize macromolecules dynamically within the crowded intracellular environment. However, the intermolecular interactions that produce condensed...
10.
Schweke H, Pacesa M, Levin T, Goverde C, Kumar P, Duhoo Y, et al.
Cell
. 2024 Feb;
187(4):999-1010.e15.
PMID: 38325366
Protein structures are essential to understanding cellular processes in molecular detail. While advances in artificial intelligence revealed the tertiary structure of proteins at scale, their quaternary structure remains mostly unknown....