Derek J Wilson
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Explore the profile of Derek J Wilson including associated specialties, affiliations and a list of published articles.
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80
Citations
1070
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Recent Articles
1.
Haas-Neill L, Meneksedag-Erol D, Chaudhry A, Novoselova M, Ashraf Q, de Araujo E, et al.
Protein Sci
. 2024 Dec;
34(1):e70022.
PMID: 39723827
The point mutation N642H of the signal transducer and activator of transcription 5B (STAT5B) protein is associated with aggressive and drug-resistant forms of leukemia. This mutation is thought to promote...
2.
Ackloo S, Li F, Szewczyk M, Seitova A, Loppnau P, Zeng H, et al.
J Med Chem
. 2024 Nov;
68(2):1092-1112.
PMID: 39495097
Target class-focused drug discovery has a strong track record in pharmaceutical research, yet public domain data indicate that many members of protein families remain unliganded. Here we present a systematic...
3.
Nie D, Tabor J, Li J, Kutera M, St-Germain J, Hanley R, et al.
Nat Chem Biol
. 2024 Jul;
20(12):1597-1607.
PMID: 38965384
Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins...
4.
Listigovers A, Lento C, Wilson D
Int J Biol Macromol
. 2024 Jun;
273(Pt 1):132868.
PMID: 38838881
Low molecular weight heparin and synthetic mimetics such as fondaparinux show different binding kinetics, protease specificity, and clinical effects. A combination of allosteric and template-mediated bridging mechanisms have been proposed...
5.
Geib T, Lento C, Marensi V, Thulasingam M, Haeggstrom J, Olsson M, et al.
Anal Sci Adv
. 2024 May;
2(5-6):263-271.
PMID: 38716151
Acetaminophen (APAP)-related toxicity is caused by the formation of -acetyl -benzoquinone imine (NAPQI), a reactive metabolite able to covalently bind to protein thiols. A targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
6.
Mann M, Wolf E, Silva M, Kwak H, Wilson B, Bolotokova A, et al.
ACS Omega
. 2024 Jan;
9(1):917-924.
PMID: 38222562
Zinc-finger ubiquitin-binding domains (ZnF-UBDs) are noncatalytic domains mostly found in deubiquitylases (DUBs) such as USP3. They represent an underexplored opportunity for the development of deubiquitylase-targeting chimeras (DUBTACs) to pharmacologically induce...
7.
Nie D, Tabor J, Li J, Kutera M, St-Germain J, Hanley R, et al.
bioRxiv
. 2023 Nov;
PMID: 37961297
Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins...
8.
Wolf E, Lento C, Pu J, Dickinson B, Wilson D
Biochemistry
. 2023 May;
62(11):1619-1630.
PMID: 37192192
The structurally conserved B-cell lymphoma 2 (Bcl-2) family of protein function to promote or inhibit apoptosis through an exceedingly complex web of specific, intrafamilial protein-protein interactions. The critical role of...
9.
Anacleto J, Lento C, Sarpe V, Maqsood A, Mehrazma B, Schriemer D, et al.
Anal Chem
. 2023 Mar;
95(9):4421-4428.
PMID: 36880265
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a rapidly growing technique for protein characterization in industry and academia, complementing the "static" picture provided by classical structural biology with information about...
10.
Chow V, Wolf E, Lento C, Wilson D
Essays Biochem
. 2023 Jan;
67(2):165-174.
PMID: 36636941
Biological macromolecules, such as proteins, nucleic acids, and carbohydrates, contain heteroatom-bonded hydrogens that undergo exchange with solvent hydrogens on timescales ranging from microseconds to hours. In hydrogen-deuterium exchange mass spectrometry...