The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2019 Aug 2

PMID 31366712

Citations 4

Authors

Sai Zhang

Joshua A Vieth

Agata Krzyzanowska

Everett K Henry

Lisa K Denzin

Mark C Siracusa

Derek B SantAngelo

Affiliations

Soon will be listed here.

Abstract

Basophils are innate immune cells associated with type 2 immunity, allergic reactions, and host defense against parasite infections. In this study, we show that the transcription factor PLZF, which is known for its essential role in the function and development of several innate lymphocyte subsets, is also important for the myeloid-derived basophil lineage. PLZF-deficient mice had decreased numbers of basophil progenitors in the bone marrow and mature basophils in multiple peripheral tissues. Functionally, PLZF-deficient basophils were less responsive to IgE activation and produced reduced amounts of IL-4. The altered function of basophils resulted in a blunted Th2 T cell response to a protein allergen. Additionally, PLZF-deficient basophils had reduced expression of the IL-18 receptor, which impacted migration to lungs. PLZF, therefore, is a major player in controlling type 2 immune responses mediated not only by innate lymphocytes but also by myeloid-derived cells.

Citing Articles

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