Dennis Keefe
Overview
Explore the profile of Dennis Keefe including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
558
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0
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Recent Articles
1.
Gautam M, Genc B, Helmold B, Ahrens A, Kuka J, Makrecka-Kuka M, et al.
Neurobiol Dis
. 2023 Jan;
178:106022.
PMID: 36716828
Mitochondrial defects are one of the common underlying causes of neuronal vulnerability in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), and TDP-43 pathology is the most commonly observed proteinopathy....
2.
Albertine K, Dahl M, Rebentisch A, Dawson E, Nabi A, Bowen S, et al.
Pediatr Res
. 2022 Aug;
93(6):1528-1538.
PMID: 36030318
Background: Low levels of insulin-like growth factor-1 (IGF-1) protein in preterm human infants are associated with bronchopulmonary dysplasia (BPD). We used our preterm lamb model of BPD to determine (1)...
3.
Grosser J, Fehrman R, Keefe D, Redmon M, Nickells R
BMC Res Notes
. 2021 May;
14(1):198.
PMID: 34022923
Objective: Elamipretide (SS31) is a mitochondria-targeted peptide that has reported functions of stabilizing mitochondrial cristae structure and improving mitochondrial bioenergetics. Several studies have documented cell protective features of this peptide,...
4.
Bosco J, Zhou Z, Gabriels S, Verma M, Liu N, Miller B, et al.
Mol Ther Methods Clin Dev
. 2021 Apr;
21:369-381.
PMID: 33898634
Duchenne muscular dystrophy is characterized by structural degeneration of muscle, which is exacerbated by localized functional ischemia due to loss of nitric oxide synthase-induced vasodilation. Treatment strategies aimed at increasing...
5.
Verma M, Shimizu-Motohashi Y, Asakura Y, Ennen J, Bosco J, Zhou Z, et al.
PLoS Genet
. 2019 Dec;
15(12):e1008468.
PMID: 31877123
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease in which the dystrophin coding for a membrane stabilizing protein is mutated. Recently, the vasculature has also shown to be...
6.
Wallace B, Peisl A, Seedorf G, Nowlin T, Kim C, Bosco J, et al.
Am J Respir Crit Care Med
. 2017 Dec;
197(6):776-787.
PMID: 29268623
Rationale: Pregnancies complicated by antenatal stress, including preeclampsia (PE) and chorioamnionitis (CA), increase the risk for bronchopulmonary dysplasia (BPD) in preterm infants, but biologic mechanisms linking prenatal factors with BPD...
7.
Schug T, Heindel J, Camacho L, Delclos K, Howard P, Johnson A, et al.
Reprod Toxicol
. 2013 Jun;
40:35-40.
PMID: 23747832
Recently, medical research has seen a strong push toward translational research, or "bench to bedside" collaborations, that strive to enhance the utility of laboratory science for improving medical treatment. The...
8.
Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, et al.
Nat Immunol
. 2011 Jun;
12(8):770-7.
PMID: 21685908
How the pore-forming protein perforin delivers apoptosis-inducing granzymes to the cytosol of target cells is uncertain. Perforin induces a transient Ca2+ flux in the target cell, which triggers a process...
9.
Keefe D, Parng C, Lundberg D, Ray S, Martineau-Bosco J, Leng C, et al.
Autoimmunity
. 2010 Apr;
43(8):628-39.
PMID: 20402568
SHG2210, a fusion protein containing the N-terminus of human nicotinic acetylcholine receptor α (AchR-α; aa1-210) and human transferrin (TF), was characterized as a potential therapeutic for myasthenia gravis (MG) caused...
10.
Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, et al.
Blood
. 2009 Dec;
115(8):1582-93.
PMID: 20038786
Cytotoxic T lymphocytes and natural killer cells destroy target cells via the polarized exocytosis of lytic effector proteins, perforin and granzymes, into the immunologic synapse. How these molecules enter target...