Dennis Keefe
Overview
Explore the profile of Dennis Keefe including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
558
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0
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Recent Articles
11.
Keefe D, Hess D, Bosco J, Tzartos S, Powell J, Lamsa J, et al.
Cytometry B Clin Cytom
. 2008 Oct;
76(3):206-12.
PMID: 18825779
Background: Myasthenia gravis (MG) is an autoimmune disease affecting approximately 40,000 patients in the United States. One of the major mechanisms of disease pathology in MG is the binding, internalization,...
12.
Zhu P, Zhang D, Chowdhury D, Martinvalet D, Keefe D, Shi L, et al.
EMBO Rep
. 2006 Jan;
7(4):431-7.
PMID: 16440001
Granzyme A (GzmA) induces caspase-independent cell death with morphological features of apoptosis. Here, we show that GzmA at nanomolar concentrations cleaves Ku70, a key double-strand break repair (DSBR) protein, in...
13.
Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, et al.
Immunity
. 2005 Sep;
23(3):249-62.
PMID: 16169498
Perforin delivers granzymes to induce target-cell apoptosis. At high concentrations, perforin multimerizes in the plasma membrane to form pores. However, whether granzymes enter target cells via membrane pores is uncertain....
14.
Speaking your patients' language. A Massachusetts health system bridges linguistic and cultural gaps
Keefe D
Healthc Exec
. 2005 Jul;
20(4):36-7.
PMID: 16033011
No abstract available.
15.
Shi L, Keefe D, Durand E, Feng H, Zhang D, Lieberman J
J Immunol
. 2005 Apr;
174(9):5456-61.
PMID: 15843543
Perforin (PFN) delivery of granzymes (Gzm) into the target cell at the immunological synapse is the major pathway for inducing apoptosis of virus-infected cells and tumors. A validated model for...