Dennis Higgins
Overview
Explore the profile of Dennis Higgins including associated specialties, affiliations and a list of published articles.
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15
Citations
390
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Recent Articles
1.
Lein P, Higgins D
Biomed Res (Aligarh)
. 2017 Dec;
7(1):101-111.
PMID: 29238133
We have examined the role of integrins in the development of dendrites in embryonic rat sympathetic neurons . Previous studies have established that exposure to a basement membrane extract (BME)...
2.
Chandrasekaran V, Lea C, Sosa J, Higgins D, Lein P
Mol Cell Neurosci
. 2015 Jun;
67:116-25.
PMID: 26079955
Previous studies have shown that bone morphogenetic proteins (BMPs) promote dendritic growth in sympathetic neurons; however, the downstream signaling molecules that mediate the dendrite promoting activity of BMPs are not...
3.
Kim W, Gonsiorek E, Barnhart C, Davare M, Engebose A, Lauridsen H, et al.
J Neurochem
. 2009 Feb;
108(4):1057-71.
PMID: 19209406
Clinical and experimental evidence suggest that statins decrease sympathetic activity, but whether peripheral mechanisms involving direct actions on post-ganglionic sympathetic neurons contribute to this effect is not known. Because tonic...
4.
Bucelli R, Gonsiorek E, Kim W, Bruun D, Rabin R, Higgins D, et al.
J Pharmacol Exp Ther
. 2007 Dec;
324(3):1172-80.
PMID: 18079356
Clinical and experimental observations suggest that statins may be useful for treating diseases presenting with predominant neurogenic inflammation, but the mechanism(s) mediating this potential therapeutic effect are poorly understood. In...
5.
Kim W, Fayazi Z, Bao X, Higgins D, Kazemi-Esfarjani P
Mol Cell Neurosci
. 2005 Jun;
29(4):536-44.
PMID: 15936212
Intracellular inclusions of abnormally long polyglutamine tracts and neurotoxicity are the hallmarks of several hereditary neurodegenerative disorders, including Huntington's disease (HD). In Drosophila melanogaster, dMLF, an ortholog of human myeloid...
6.
Edelman A, Kim W, Higgins D, Goldstein E, Oberdoerster M, Sigurdson W
J Biol Chem
. 2004 Dec;
280(9):8531-43.
PMID: 15611072
The microtubule (MT)-associated DCX protein plays an essential role in the development of the mammalian cerebral cortex. We report on the identification of a protein kinase, doublecortin kinase-2 (DCK2), with...
7.
Kim W, Horbinski C, Sigurdson W, Higgins D
J Neurochem
. 2004 Dec;
91(5):1044-56.
PMID: 15569248
At least nine neurodegenerative disorders are caused by expansion of polyglutamine repeats in various genes. This expansion induces the formation of nuclear inclusions (NI) within various cell types. In this...
8.
Shen W, Finnegan S, Lein P, Sullivan S, Slaughter M, Higgins D
Eur J Neurosci
. 2004 Sep;
20(8):2031-7.
PMID: 15450082
Bone morphogenetic proteins (BMPs) are required for the development of retina, but their role in the mature eye is unknown. We therefore examined the expression of BMP-7 in adult human...
9.
Kim I, Drahushuk K, Kim W, Gonsiorek E, Lein P, Andres D, et al.
J Neurosci
. 2004 Apr;
24(13):3304-12.
PMID: 15056710
NGF activates several signaling cascades in sympathetic neurons. We examined how activation of one of these cascades, the ERK/MAP (extracellular signal-regulated kinase/mitogen-activated protein) kinase pathway, affects dendritic growth in these...
10.
Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines
Kaur N, Kim I, Higgins D, Halvorsen S
J Neurochem
. 2003 Sep;
87(2):437-47.
PMID: 14511121
Many cytokines mediate their effects through Jak/STAT signaling pathways providing many opportunities for cross-talk between different cytokines. We examined the interaction between two cytokine families, gp130-related cytokines and interferon-gamma (IFN-gamma),...