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Dennis E Shasha

Explore the profile of Dennis E Shasha including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 1071
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Recent Articles
1.
Zhu Q, Mulligan V, Shasha D, Shasha D
bioRxiv . 2024 Jul; PMID: 39005429
Rational computational design is crucial to the pursuit of novel drugs and therapeutic agents. Meso-scale cyclic peptides, which consist of 7-40 amino acid residues, are of particular interest due to...
2.
Cirrone J, Brooks M, Bonneau R, Coruzzi G, Shasha D
Sci Rep . 2020 Aug; 10(1):14141. PMID: 32811842
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
3.
Cirrone J, Brooks M, Bonneau R, Coruzzi G, Shasha D
Sci Rep . 2020 Apr; 10(1):6804. PMID: 32321967
The ability to accurately predict the causal relationships from transcription factors to genes would greatly enhance our understanding of transcriptional dynamics. This could lead to applications in which one or...
4.
Kocak M, Ramirez D, Erkip E, Shasha D
IEEE Trans Pattern Anal Mach Intell . 2019 Aug; 43(2):663-678. PMID: 31380747
SafePredict is a novel meta-algorithm that works with any base prediction algorithm for online data to guarantee an arbitrarily chosen correctness rate, 1-ϵ, by allowing refusals. Allowing refusals means that...
5.
Poultney C, Butterfoss G, Gutwein M, Drew K, Gresham D, Gunsalus K, et al.
PLoS One . 2011 Sep; 6(9):e23947. PMID: 21912654
Temperature-sensitive (ts) mutations are mutations that exhibit a mutant phenotype at high or low temperatures and a wild-type phenotype at normal temperature. Temperature-sensitive mutants are valuable tools for geneticists, particularly...
6.
Krouk G, Mirowski P, LeCun Y, Shasha D, Coruzzi G
Genome Biol . 2010 Dec; 11(12):R123. PMID: 21182762
Background: Nitrate, acting as both a nitrogen source and a signaling molecule, controls many aspects of plant development. However, gene networks involved in plant adaptation to fluctuating nitrate environments have...
7.
Chen H, Bandyopadhyay S, Shasha D, Birnbaum K
BMC Evol Biol . 2010 Nov; 10:357. PMID: 21087504
Background: Gene duplication can lead to genetic redundancy, which masks the function of mutated genes in genetic analyses. Methods to increase sensitivity in identifying genetic redundancy can improve the efficiency...
8.
Katari M, Nowicki S, Aceituno F, Nero D, Kelfer J, Thompson L, et al.
Plant Physiol . 2009 Dec; 152(2):500-15. PMID: 20007449
Data generation is no longer the limiting factor in advancing biological research. In addition, data integration, analysis, and interpretation have become key bottlenecks and challenges that biologists conducting genomic research...
9.
Gutierrez R, Gifford M, Poultney C, Wang R, Shasha D, Coruzzi G, et al.
J Exp Bot . 2007 May; 58(9):2359-67. PMID: 17470441
Nitrate is both a nutrient and a potent signal that stimulates plant growth. Initial experiments in the late 1950s showing that nitrate enhances nitrate reductase (NR) activity after several hours...
10.
Gutierrez R, Lejay L, Dean A, Chiaromonte F, Shasha D, Coruzzi G
Genome Biol . 2007 Jan; 8(1):R7. PMID: 17217541
Background: Carbon (C) and nitrogen (N) metabolites can regulate gene expression in Arabidopsis thaliana. Here, we use multi-network analysis of microarray data to identify molecular networks regulated by C and...