Denis I Crane
Overview
Explore the profile of Denis I Crane including associated specialties, affiliations and a list of published articles.
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28
Citations
436
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Recent Articles
1.
Rishi G, Bhatia M, Secondes E, Melino M, Crane D, Subramaniam V
Biochim Biophys Acta Mol Basis Dis
. 2020 Jun;
1866(10):165882.
PMID: 32565019
Peroxisomes are organelles, abundant in the liver, involved in a variety of cellular functions, including fatty acid metabolism, plasmalogen synthesis and metabolism of reactive oxygen species. Several inherited disorders are...
2.
Rahim R, St John J, Crane D, Meedeniya A
Mol Cell Neurosci
. 2017 Dec;
88:16-32.
PMID: 29187321
Zellweger syndrome (ZS), a neonatal lethal disorder arising from defective peroxisome biogenesis, features profound neuroanatomical abnormalities and brain dysfunction. Here we used mice with brain-restricted inactivation of the peroxisome biogenesis...
3.
Lee M, Sumpter Jr R, Zou Z, Sirasanagandla S, Wei Y, Mishra P, et al.
EMBO Rep
. 2016 Nov;
18(1):48-60.
PMID: 27827795
PEX13 is an integral membrane protein on the peroxisome that regulates peroxisomal matrix protein import during peroxisome biogenesis. Mutations in PEX13 and other peroxin proteins are associated with Zellweger syndrome...
4.
Rahim R, Chen M, Nourse C, Meedeniya A, Crane D
Neuroscience
. 2016 Aug;
334:201-213.
PMID: 27514574
Zellweger syndrome (ZS) is a peroxisome biogenesis disorder that involves significant neuropathology, the molecular basis of which is still poorly understood. Using a mouse model of ZS with brain-restricted deficiency...
5.
Wali G, Sutharsan R, Fan Y, Stewart R, Tello Velasquez J, Sue C, et al.
Sci Rep
. 2016 May;
6:27004.
PMID: 27229699
Hereditary spastic paraplegia (HSP) is an inherited neurological condition that leads to progressive spasticity and gait abnormalities. Adult-onset HSP is most commonly caused by mutations in SPAST, which encodes spastin...
6.
Wright K, Mundorff A, Chaseling J, Forrest A, Maguire C, Crane D
Forensic Sci Int
. 2015 Apr;
250:91-7.
PMID: 25828381
The international disaster victim identification (DVI) response to the Boxing Day tsunami, led by the Royal Thai Police in Phuket, Thailand, was one of the largest and most complex in...
7.
Fan Y, Wali G, Sutharsan R, Bellette B, Crane D, Sue C, et al.
Biol Open
. 2014 May;
3(6):494-502.
PMID: 24857849
Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous group of disorders, diagnosed by progressive gait disturbances with muscle weakness and spasticity, for which there are no treatments targeted at the...
8.
Crane D
Neurochem Int
. 2014 Mar;
69:1-8.
PMID: 24607700
Zellweger syndrome (ZS) is a neonatal-lethal genetic disease that affects all tissues, and features neuropathology that involves primary developmental defects as well as neurodegeneration. Neuropathological changes include abnormal neuronal migration...
9.
Tan T, Crawford D, Jaskowski L, Subramaniam V, Clouston A, Crane D, et al.
Lab Invest
. 2013 Oct;
93(12):1295-312.
PMID: 24126888
Endoplasmic reticulum (ER) stress is an important pathogenic mechanism for alcoholic (ALD) and nonalcoholic fatty liver disease (NAFLD). Iron overload is an important cofactor for liver injury in ALD and...
10.
Grant P, Ahlemeyer B, Karnati S, Berg T, Stelzig I, Nenicu A, et al.
Histochem Cell Biol
. 2013 Aug;
140(4):423-42.
PMID: 23959168
Catalase and ABCD3 are frequently used as markers for the localization of peroxisomes in morphological experiments. Their abundance, however, is highly dependent on metabolic demands, reducing the validity of analyses...