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Denis Evseenko

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Articles 54
Citations 1204
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Recent Articles
1.
Sarkar A, Gallo M, Bell J, Mayfield C, Ball J, Ayad M, et al.
Bioengineering (Basel) . 2025 Jan; 12(1). PMID: 39851303
regional gene therapy is a promising tissue-engineering strategy for bone regeneration: osteogenic mesenchymal stem cells (MSCs) can be genetically modified to express an osteoinductive stimulus (e.g., bone morphogenetic protein-2), seeded...
2.
Thiruppathy M, Teubner L, Roberts R, Lasser M, Lasser M, Moscatello A, et al.
Nature . 2025 Jan; PMID: 39788155
How new structures emerge during evolution has long fascinated biologists. An example is how the diminutive bones of the mammalian middle ear arose from ancestral fish jawbones. By contrast, the...
3.
Lee Y, Tassey J, Sarkar A, Levi J, Lee S, Liu N, et al.
Sci Rep . 2024 Dec; 14(1):31151. PMID: 39732741
Interleukin-6 (IL-6) is a major pro-inflammatory cytokine that demonstrates a robust correlation with age and body mass index (BMI) as part of the senescence-associated secretory phenotype. IL-6 cytokines also play...
4.
Lee Y, Sarkar A, Tassey J, Levi J, Lee S, Liu N, et al.
bioRxiv . 2024 Apr; PMID: 38645030
Interleukin-6 (IL-6) is a major pro-inflammatory cytokine for which the levels in plasma demonstrate a robust correlation with age and body mass index (BMI) as part of the senescence-associated secretory...
5.
Li A, Anbuchelvan M, Fathi A, Abu-Zahra M, Evseenko D, Petrigliano F, et al.
Front Cell Dev Biol . 2023 May; 11:1173794. PMID: 37143896
Chronic muscle injuries, such as massive rotator cuff tears, are associated with progressive muscle wasting, fibrotic scarring, and intramuscular fat accumulation. While progenitor cell subsets are usually studied in culture...
6.
Shkhyan R, Flynn C, Lamoure E, Sarkar A, Van Handel B, Li J, et al.
Sci Transl Med . 2023 Mar; 15(688):eabq2395. PMID: 36947594
Adult mammals are incapable of multitissue regeneration, and augmentation of this potential may shift current therapeutic paradigms. We found that a common co-receptor of interleukin 6 (IL-6) cytokines, glycoprotein 130...
7.
Sarkar A, Liu N, Magallanes J, Tassey J, Lee S, Shkhyan R, et al.
Aging Cell . 2023 Jan; 22(2):e13773. PMID: 36638270
Epigenetic mechanisms guiding articular cartilage regeneration and age-related disease such as osteoarthritis (OA) are poorly understood. STAT3 is a critical age-patterned transcription factor highly active in fetal and OA chondrocytes,...
8.
Collon K, Bell J, Gallo M, Chang S, Bougioukli S, Sugiyama O, et al.
Gene Ther . 2022 Oct; 30(3-4):369-376. PMID: 36216880
Human adipose-derived mesenchymal stem cells (ASCs) transduced with a lentiviral vector system to express bone morphogenetic protein 2 (LV-BMP-2) have been shown to reliably heal bone defects in animal models....
9.
Magallanes J, Liu N, Zhang J, Ouyang Y, Mkaratigwa T, Bian F, et al.
Front Cell Dev Biol . 2022 Sep; 10:954028. PMID: 36092701
Complex injury and open reconstructive surgeries of the knee often lead to joint dysfunction that may alter the normal biomechanics of the joint. Two major complications that often arise are...
10.
Heckmann N, Chung B, Kang H, Chang M, Wang J, Weber A, et al.
J Orthop Res . 2022 Jun; 41(3):692-697. PMID: 35730424
Tranexamic acid (TXA) effectively reduces blood loss and transfusion risk during total joint arthroplasty. Additionally, intraoperative irrigation with various antiseptic solutions is often utilized for the management and prevention of...