Degong Ruan
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Explore the profile of Degong Ruan including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
292
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Recent Articles
1.
Chau C, To A, Au-Yeung R, Tang K, Xiang Y, Ruan D, et al.
Sci Rep
. 2024 Apr;
14(1):8781.
PMID: 38627497
SARS-CoV-2 provokes devastating tissue damage by cytokine release syndrome and leads to multi-organ failure. Modeling the process of immune cell activation and subsequent tissue damage is a significant task. Organoids...
2.
Chen Y, Ye X, Zhong Y, Kang X, Tang Y, Zhu H, et al.
Dev Cell
. 2024 Apr;
59(12):1506-1522.e11.
PMID: 38582082
The commitment and differentiation of human placental progenitor cytotrophoblast (CT) cells are crucial for a successful pregnancy, but the underlying mechanism remains poorly understood. Here, we identified the transcription factor...
3.
Ruan D, Xuan Y, Tam T, Li Z, Wang X, Xu S, et al.
Nat Protoc
. 2024 Mar;
19(6):1710-1749.
PMID: 38509352
Pigs share anatomical and physiological traits with humans and can serve as a large-animal model for translational medicine. Bona fide porcine pluripotent stem cells (PSCs) could facilitate testing cell and...
4.
Zhang Q, Lee C, Yang T, Li J, Zeng Q, Liu X, et al.
Sci Adv
. 2023 Nov;
9(44):eadi4777.
PMID: 37922358
Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with defective trophoblast differentiation and functions at implantation, but manifestation of its phenotypes is in late pregnancy. There is no reliable...
5.
Xu S, Wang S, Tam T, Liu P, Ruan D
STAR Protoc
. 2023 Jun;
4(2):102354.
PMID: 37300826
Human trophoblast development study has long been limited by the lack of suitable materials. Here we present a detailed protocol for the differentiation of human expanded potential stem cells (hEPSCs)...
6.
Ruan D, Ye Z, Yuan S, Li Z, Zhang W, Ong C, et al.
Cell Rep Med
. 2022 Dec;
3(12):100849.
PMID: 36495872
Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives are susceptible to SARS-CoV-2 infection,...
7.
Lee C, Chen Z, Zhang Q, Guo Y, Ng V, Zhang B, et al.
Clin Transl Med
. 2022 Jun;
12(6):e826.
PMID: 35653421
No abstract available.
8.
Gao X, Ruan D, Liu P
Methods Mol Biol
. 2020 Nov;
2239:199-211.
PMID: 33226621
The development of porcine expanded potential stem cells (pEPSCs) provides an invaluable tool for investigation of porcine stem cell pluripotency and opens a venue for research in biotechnology, agriculture, and...
9.
Gao X, Nowak-Imialek M, Chen X, Chen D, Herrmann D, Ruan D, et al.
Nat Cell Biol
. 2019 Jun;
21(6):687-699.
PMID: 31160711
We recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres by inhibiting the critical molecular pathways that predispose their differentiation. EPSCs had enriched molecular signatures of blastomeres and...
10.
Wu H, Liu Q, Shi H, Xie J, Zhang Q, Ouyang Z, et al.
Cell Mol Life Sci
. 2018 Apr;
75(19):3593-3607.
PMID: 29637228
CRISPR/Cpf1 features a number of properties that are distinct from CRISPR/Cas9 and provides an excellent alternative to Cas9 for genome editing. To date, genome engineering by CRISPR/Cpf1 has been reported...