Deepak Raina
Overview
Explore the profile of Deepak Raina including associated specialties, affiliations and a list of published articles.
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29
Citations
1422
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Recent Articles
11.
Raina D, Ahmad R, Rajabi H, Panchamoorthy G, Kharbanda S, Kufe D
Int J Oncol
. 2011 Dec;
40(5):1643-9.
PMID: 22200620
The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas and contributes to the malignant phenotype. The MUC1-C transmembrane subunit contains a CQC motif in the cytoplasmic domain that...
12.
Raina D, Kosugi M, Ahmad R, Panchamoorthy G, Rajabi H, Alam M, et al.
Mol Cancer Ther
. 2011 Mar;
10(5):806-16.
PMID: 21421804
Non-small cell lung cancer (NSCLC) cells are often associated with constitutive activation of the phosphoinositide 3-kinase (PI3K) → Akt → mTOR pathway. The mucin 1 (MUC1) heterodimeric glycoprotein is aberrantly...
13.
Joshi M, Ahmad R, Yin L, Raina D, Rajabi H, Bubley G, et al.
Mol Cancer Ther
. 2009 Nov;
8(11):3056-65.
PMID: 19887552
Human prostate cancers are dependent on the androgen receptor for their progression. The MUC1 heterodimeric oncoprotein is aberrantly overexpressed in prostate cancers; however, it is not known if MUC1 is...
14.
Ahmad R, Raina D, Joshi M, Kawano T, Ren J, Kharbanda S, et al.
Cancer Res
. 2009 Aug;
69(17):7013-21.
PMID: 19706766
Nuclear factor-kappaB (NF-kappaB) is constitutively activated in diverse human malignancies. The mucin 1 (MUC1) oncoprotein is overexpressed in human carcinomas and, like NF-kappaB, blocks cell death and induces transformation. The...
15.
Raina D, Ahmad R, Joshi M, Yin L, Wu Z, Kawano T, et al.
Cancer Res
. 2009 Jun;
69(12):5133-41.
PMID: 19491255
The mucin 1 (MUC1) oncoprotein is aberrantly overexpressed by approximately 90% of human breast cancers. However, there are no effective agents that directly inhibit MUC1 and induce death of breast...
16.
Raina D, Ahmad R, Chen D, Kumar S, Kharbanda S, Kufe D
Cancer Biol Ther
. 2008 Nov;
7(12):1959-67.
PMID: 18981727
The MUC1 oncoprotein interacts with the c-Abl tyrosine kinase and blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. Mutation of the MUC1 cytoplasmic domain at Tyr-60...
17.
Agata N, Ahmad R, Kawano T, Raina D, Kharbanda S, Kufe D
Cancer Res
. 2008 Aug;
68(15):6136-44.
PMID: 18676836
Stimulation of the death receptor superfamily induces the activation of caspase-8 and thereby the apoptotic response. The MUC1 oncoprotein is aberrantly overexpressed by diverse human malignancies and inhibits stress-induced apoptosis....
18.
Ahmad R, Raina D, Meyer C, Kufe D
Cancer Res
. 2008 Apr;
68(8):2920-6.
PMID: 18413761
The C-28 methyl ester of the oleane triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO-Me) induces apoptosis of human cancer cells by disrupting redox balance and is in clinical trials. CDDO-Me contains alpha,beta-unsaturated carbonyl...
19.
Kawano T, Ito M, Raina D, Wu Z, Rosenblatt J, Avigan D, et al.
Cancer Res
. 2007 Dec;
67(24):11576-84.
PMID: 18089786
Chronic myelogenous leukemia (CML) results from expression of the Bcr-Abl fusion protein in hematopoietic stem cells. The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas. The present studies...
20.
Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S, et al.
Nat Cell Biol
. 2007 Nov;
9(12):1419-27.
PMID: 18037881
Nuclear factor-kappaB (NF-kappaB) is constitutively activated in diverse human malignancies by mechanisms that are not understood. The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas and, similarly to NF-kappaB,...