Deepak Nihalani
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Explore the profile of Deepak Nihalani including associated specialties, affiliations and a list of published articles.
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43
Citations
1164
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Recent Articles
1.
Arif E, Solanki A, Rahman B, Wolf B, Schnellmann R, Nihalani D, et al.
Pharmacol Rep
. 2024 Apr;
76(3):612-621.
PMID: 38668812
Background: Podocytes have a remarkable ability to recover from injury; however, little is known about the recovery mechanisms involved in this process. We recently showed that formoterol, a long-acting β-adrenergic...
2.
Solanki A, Arif E, Srivastava P, Furcht C, Rahman B, Wen P, et al.
J Biol Chem
. 2021 Aug;
297(3):101079.
PMID: 34391780
Phosphorylation (activation) and dephosphorylation (deactivation) of the slit diaphragm proteins NEPHRIN and NEPH1 are critical for maintaining the kidney epithelial podocyte actin cytoskeleton and, therefore, proper glomerular filtration. However, the...
3.
Loss of Motor Protein MYO1C Causes Rhodopsin Mislocalization and Results in Impaired Visual Function
Solanki A, Biswal M, Walterhouse S, Martin R, Kondkar A, Knolker H, et al.
Cells
. 2021 Jun;
10(6).
PMID: 34073294
Unconventional myosins, linked to deafness, are also proposed to play a role in retinal cell physiology. However, their direct role in photoreceptor function remains unclear. We demonstrate that systemic loss...
4.
Arif E, Wang C, Swiderska-Syn M, Solanki A, Rahman B, Manka P, et al.
Am J Physiol Gastrointest Liver Physiol
. 2021 Apr;
320(6):G1044-G1053.
PMID: 33908271
Myosin 1c (Myo1c) is an unconventional myosin that modulates signaling pathways involved in tissue injury and repair. In this study, we observed that Myo1c expression is significantly upregulated in human...
5.
Solanki A, Kondkar A, Fogerty J, Su Y, Kim S, Lipschutz J, et al.
Cells
. 2020 May;
9(5).
PMID: 32365517
Dietary vitamin A/all- retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds...
6.
Hammad S, Twal W, Arif E, Semler A, Klein R, Nihalani D
Genes (Basel)
. 2020 Feb;
11(2).
PMID: 32045989
Sphingolipids are bioactive lipids associated with cellular membranes and plasma lipoproteins, and their synthesis and degradation are tightly regulated. We have previously determined that low plasma concentrations of certain ceramide...
7.
Solanki A, Srivastava P, Rahman B, Lipschutz J, Nihalani D, Arif E
Int J Mol Sci
. 2020 Jan;
21(1).
PMID: 31906131
Podocytes have a unique structure that supports glomerular filtration function, and many glomerular diseases result in loss of this structure, leading to podocyte dysfunction and ESRD (end stage renal disease)....
8.
Solanki A, Widmeier E, Arif E, Sharma S, Daga A, Srivastava P, et al.
Kidney Int
. 2019 Sep;
96(4):883-889.
PMID: 31472902
Steroid-resistant nephrotic syndrome is a frequent cause of chronic kidney disease almost inevitably progressing to end-stage renal disease. More than 58 monogenic causes of SRNS have been discovered and majority...
9.
Arif E, Solanki A, Srivastava P, Rahman B, Fitzgibbon W, Deng P, et al.
Kidney Int
. 2019 Jul;
96(3):656-673.
PMID: 31262488
Podocytes have limited ability to recover from injury. Here, we demonstrate that increased mitochondrial biogenesis, to meet the metabolic and energy demand of a cell, accelerates podocyte recovery from injury....
10.
Arif E, Solanki A, Srivastava P, Rahman B, Tash B, Holzman L, et al.
Kidney Int
. 2019 May;
96(1):139-158.
PMID: 31097328
Transforming growth factor-β (TGF-β) is known to play a critical role in the pathogenesis of many progressive podocyte diseases. However, the molecular mechanisms regulating TGF-β signaling in podocytes remain unclear....