Deepak Khuperkar
Overview
Explore the profile of Deepak Khuperkar including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
260
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0
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Recent Articles
1.
Lin J, Khuperkar D, Pavlou S, Makarchuk S, Patikas N, Lee F, et al.
EMBO J
. 2023 May;
42(14):e113168.
PMID: 37248947
Enhanced expression of the cold-shock protein RNA binding motif 3 (RBM3) is highly neuroprotective both in vitro and in vivo. Whilst upstream signalling pathways leading to RBM3 expression have been...
2.
Chavan S, Khuperkar D, Lonare A, Panigrahi S, Bellare J, Rapole S, et al.
Cell Mol Life Sci
. 2022 Jul;
79(7):392.
PMID: 35779171
Small extracellular vesicle (sEV)-mediated intercellular communication regulates multiple aspects of growth and development in multicellular organisms. However, the mechanism underlying cargo recruitment into sEVs is currently unclear. We show that...
3.
Deshmukh P, Singh A, Khuperkar D, Joseph J
Biochem Biophys Res Commun
. 2021 May;
559:230-237.
PMID: 33962210
MicroRNA (miRNA)-mediated translational suppression of mRNAs is involved in the regulation of multiple cellular processes. A recent study showed that Nup358, a protein mutated in a neurological disorder called acute...
4.
Khuperkar D, Hoek T, Sonneveld S, Verhagen B, Boersma S, Tanenbaum M
Nat Protoc
. 2020 Feb;
15(4):1371-1398.
PMID: 32076351
mRNA translation is a key step in gene expression. Proper regulation of translation efficiency ensures correct protein expression levels in the cell, which is essential to cell function. Different methods...
5.
Wu J, Zaccara S, Khuperkar D, Kim H, Tanenbaum M, Jaffrey S
Nat Methods
. 2019 Sep;
16(9):862-865.
PMID: 31471614
Fluorogenic RNA aptamers bind and activate the fluorescence of otherwise nonfluorescent dyes. However, fluorogenic aptamers are limited by the small number of fluorogenic dyes suitable for use in live cells....
6.
Boersma S, Khuperkar D, Verhagen B, Sonneveld S, Grimm J, Lavis L, et al.
Cell
. 2019 Jun;
178(2):458-472.e19.
PMID: 31178119
mRNA translation is a key step in decoding genetic information. Genetic decoding is surprisingly heterogeneous because multiple distinct polypeptides can be synthesized from a single mRNA sequence. To study translational...
7.
Hoek T, Khuperkar D, Lindeboom R, Sonneveld S, Verhagen B, Boersma S, et al.
Mol Cell
. 2019 Jun;
75(2):324-339.e11.
PMID: 31155380
Nonsense-mediated decay (NMD) is a surveillance system that degrades mRNAs containing a premature termination codon (PTC) and plays important roles in protein homeostasis and disease. The efficiency of NMD is...
8.
Khuperkar D, Kamble A, Singh A, Ghate A, Nawadkar R, Sahu A, et al.
Virology
. 2017 Oct;
512:151-160.
PMID: 28963881
Vaccinia virus (VACV), a member of the Poxviridae family, uses cytoplasmic factories for its replication. Recent studies indicated that VACV infection requires a set of nucleoporins. However, how the nucleoporins...
9.
Sahoo M, Gaikwad S, Khuperkar D, Ashok M, Helen M, Yadav S, et al.
EMBO Rep
. 2017 Jan;
18(2):241-263.
PMID: 28039207
MicroRNA (miRNA)-guided mRNA repression, mediated by the miRNA-induced silencing complex (miRISC), is an important component of post-transcriptional gene silencing. However, how miRISC identifies the target mRNA in vivo is not...
10.
Yadav S, Magre I, Singh A, Khuperkar D, Joseph J
Sci Rep
. 2016 Sep;
6:34100.
PMID: 27682244
Atypical PKC (aPKC) family members are involved in regulation of diverse cellular processes, including cell polarization. aPKCs are known to be activated by phosphorylation of specific threonine residues in the...