Deepak Chatterjee
Overview
Explore the profile of Deepak Chatterjee including associated specialties, affiliations and a list of published articles.
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16
Citations
95
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Recent Articles
1.
Racca J, Chatterjee D, Chen Y, Rai R, Yang Y, Georgiadis M, et al.
Front Endocrinol (Lausanne)
. 2022 Dec;
13:1029177.
PMID: 36568077
Y-encoded transcription factor SRY initiates male differentiation in therian mammals. This factor contains a high-mobility-group (HMG) box, which mediates sequence-specific DNA binding with sharp DNA bending. A companion article in...
2.
Jarosinski M, Chen Y, Varas N, Dhayalan B, Chatterjee D, Weiss M
J Clin Endocrinol Metab
. 2021 Dec;
107(4):909-928.
PMID: 34850005
Design of "first-generation" insulin analogues over the past 3 decades has provided pharmaceutical formulations with tailored pharmacokinetic (PK) and pharmacodynamic (PD) properties. Application of a molecular tool kit-integrating protein sequence,...
3.
Dhayalan B, Chatterjee D, Chen Y, Weiss M
Front Endocrinol (Lausanne)
. 2021 Oct;
12:754693.
PMID: 34659132
Insight into folding mechanisms of proinsulin has been provided by analysis of dominant diabetes-associated mutations in the human insulin gene (). Such mutations cause pancreatic β-cell dysfunction due to toxic...
4.
Zhiping L, Ong L, Chatterjee D, Tan S, Bhattacharjya S
Biochim Biophys Acta Gen Subj
. 2021 Sep;
1865(12):130005.
PMID: 34509570
Background: Cytoskeletal protein filamin A is critical for the outside-in signaling of integrins. Although molecular mechanisms of filamin-integrin interactions are not fully understood. Mostly, the membrane distal (MD) part of...
5.
Jarosinski M, Dhayalan B, Chen Y, Chatterjee D, Varas N, Weiss M
Mol Metab
. 2021 Aug;
52:101325.
PMID: 34428558
Background: The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the stabilization of animal insulin formulations...
6.
Chen Y, Gleaton J, Yang Y, Dhayalan B, Phillips N, Liu Y, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(30).
PMID: 34290145
Insulin-signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations, their binding leads to structural reorganization. To test the functional coupling between insulin's "hinge opening"...
7.
Dhayalan B, Chatterjee D, Chen Y, Weiss M
Mol Metab
. 2021 Apr;
:101229.
PMID: 33823319
Background: Dominant mutations in the human insulin gene (INS) lead to pancreatic β-cell dysfunction and diabetes mellitus (DM) due to toxic misfolding of a mutant proinsulin. Analogous to a classical...
8.
Jarosinski M, Dhayalan B, Rege N, Chatterjee D, Weiss M
Diabetologia
. 2021 Mar;
64(5):1016-1029.
PMID: 33710398
Insulin replacement therapy for diabetes mellitus seeks to minimise excursions in blood glucose concentration above or below the therapeutic range (hyper- or hypoglycaemia). To mitigate acute and chronic risks of...
9.
Chatterjee D, DSouza A, Zhang Y, Bin W, Tan S, Bhattacharjya S
J Mol Biol
. 2018 Sep;
430(21):4419-4430.
PMID: 30243836
Integrins are hetero-dimeric (α and β subunits) type I transmembrane proteins that facilitate cell adhesion and migration. The cytoplasmic tails (CTs) of integrins interact with a plethora of intra-cellular proteins...
10.
Chatterjee D, Zhiping L, Tan S, Bhattacharjya S
Sci Rep
. 2018 Apr;
8(1):5490.
PMID: 29615775
Integrins are transmembrane proteins that mediate cell adhesion and migration. Each integrin is a heterodimer formed by an α and a β subunit. A large number of cytoplasmic proteins interact...