Deepa Ajit
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Explore the profile of Deepa Ajit including associated specialties, affiliations and a list of published articles.
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22
Citations
628
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Recent Articles
1.
Cozzolino K, Sanford L, Hunter S, Molison K, Erickson B, Courvan M, et al.
Elife
. 2025 Feb;
13.
PMID: 39928031
Hyperactive interferon (IFN) signaling is a hallmark of Down syndrome (DS), a condition caused by Trisomy 21 (T21); strategies that normalize IFN signaling could benefit this population. Mediator-associated kinases CDK8...
2.
Dalal S, Ajit D, Friesen C, Shakhnovich V, Singh M, Colombo J, et al.
J Pediatr Gastroenterol Nutr
. 2024 Aug;
79(5):991-999.
PMID: 39149805
Objective: In functional dyspepsia patients, duodenal mucosal eosinophilia has been associated with early satiety but is not present in all patients suggesting varied pathways to symptom generation. The objective of...
3.
Necarsulmer J, Simon J, Evangelista B, Chen Y, Tian X, Nafees S, et al.
Elife
. 2023 Oct;
12.
PMID: 37819053
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic acid-binding protein TDP-43 and subsequent neuronal dysfunction....
4.
Cozzolino K, Sanford L, Hunter S, Molison K, Erickson B, Courvan M, et al.
bioRxiv
. 2023 Jul;
PMID: 37461585
Hyperactive interferon (IFN) signaling is a hallmark of Down syndrome (DS), a condition caused by trisomy 21 (T21); strategies that normalize IFN signaling could benefit this population. Mediator-associated kinases CDK8...
5.
Creighton B, Afriyie S, Ajit D, Casingal C, Voos K, Reger J, et al.
Elife
. 2021 Nov;
10.
PMID: 34812142
Variants in the high confident autism spectrum disorder (ASD) gene target both ubiquitously expressed 220 kDa ankyrin-B and neurospecific 440 kDa ankyrin-B (AnkB440) isoforms. Previous work showed that knock-in mice...
6.
Cousin M, Creighton B, Breau K, Spillmann R, Torti E, Dontu S, et al.
Nat Genet
. 2021 Jul;
53(7):1006-1021.
PMID: 34211179
SPTBN1 encodes βII-spectrin, the ubiquitously expressed β-spectrin that forms micrometer-scale networks associated with plasma membranes. Mice deficient in neuronal βII-spectrin have defects in cortical organization, developmental delay and behavioral deficiencies....
7.
Trzeciakiewicz H, Ajit D, Tseng J, Chen Y, Ajit A, Tabassum Z, et al.
Nat Commun
. 2020 Nov;
11(1):5522.
PMID: 33139698
Tauopathies including Alzheimer's disease (AD) are marked by the accumulation of aberrantly modified tau proteins. Acetylated tau, in particular, has recently been implicated in neurodegeneration and cognitive decline. HDAC6 reversibly...
8.
Ajit D, Trzeciakiewicz H, Tseng J, Wander C, Chen Y, Ajit A, et al.
J Biol Chem
. 2019 Sep;
294(45):16698-16711.
PMID: 31543505
Abnormal intracellular accumulation of aggregated tau is a hallmark feature of Alzheimer's disease and other tauopathies. Pathological tau can undergo a range of post-translational modifications (PTMs) that are implicated as...
9.
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al.
Cell Rep
. 2017 Aug;
20(9):2169-2183.
PMID: 28854366
The initiating events that promote tau mislocalization and pathology in Alzheimer's disease (AD) are not well defined, partly because of the lack of endogenous models that recapitulate tau dysfunction. We...
10.
Ajit D, Simonyi A, Li R, Chen Z, Hannink M, Fritsche K, et al.
Neurochem Int
. 2016 May;
97:49-56.
PMID: 27166148
The increase in oxidative stress and inflammatory responses associated with neurodegenerative diseases has drawn considerable attention towards understanding the transcriptional signaling pathways involving NF-κB (nuclear factor kappa-light-chain-enhancer of activated B...