Debra T Hansen
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Explore the profile of Debra T Hansen including associated specialties, affiliations and a list of published articles.
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16
Citations
113
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Recent Articles
1.
Jernigan R, Logeswaran D, Doppler D, Nagaratnam N, Sonker M, Yang J, et al.
Structure
. 2023 Jan;
31(2):138-151.e5.
PMID: 36630960
NendoU from SARS-CoV-2 is responsible for the virus's ability to evade the innate immune system by cleaving the polyuridine leader sequence of antisense viral RNA. Here we report the room-temperature...
2.
Nagaratnam N, Martin-Garcia J, Yang J, Goode M, Ketawala G, Craciunescu F, et al.
PLoS One
. 2022 Aug;
17(8):e0267370.
PMID: 35913965
Francisella tularensis is an extremely infectious pathogen and a category A bioterrorism agent. It causes the highly contagious zoonosis, Tularemia. Currently, FDA approved vaccines against tularemia are unavailable. F. tularensis...
3.
Zhang S, Hansen D, Martin-Garcia J, Zook J, Pan S, Craciunescu F, et al.
Sci Rep
. 2022 Jul;
12(1):11824.
PMID: 35821229
Particulate Guanylyl Cyclase Receptor A (pGC-A) is a natriuretic peptide membrane receptor, playing a vital role in controlling cardiovascular, renal, and endocrine functions. The extracellular domain interacts with natriuretic peptides...
4.
Boyd R, Olson T, Zook J, Stein D, Aceves M, Lin W, et al.
FASEB J
. 2022 May;
36(7):e22378.
PMID: 35639414
Structural discovery of guanine nucleotide exchange factor (GEF) protein complexes is likely to become increasingly relevant with the development of new therapeutics targeting small GTPases and development of new classes...
5.
Moran M, Ramirez E, Zook J, Saarinen A, Baravati B, Goode M, et al.
PLoS One
. 2021 Jul;
16(7):e0249164.
PMID: 34260600
In the United States non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting an estimated 80 to 100 million people. It occurs in every...
6.
Olson T, Zhang S, Labban D, Kaschner E, Aceves M, Iyer S, et al.
Protein Expr Purif
. 2021 May;
185:105890.
PMID: 33971243
Human G-protein coupled receptor kinase 6 (GRK6) belongs to the GRK4 kinase subfamily of the G protein-coupled receptor kinase family which comprises of GRK1, GRK2, and GRK4. These kinases phosphorylate...
7.
Echelmeier A, Cruz Villarreal J, Messerschmidt M, Kim D, Coe J, Thifault D, et al.
Nat Commun
. 2020 Sep;
11(1):4511.
PMID: 32908128
Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) allows structure determination of membrane proteins and time-resolved crystallography. Common liquid sample delivery continuously jets the protein crystal suspension into...
8.
Robertson K, Truong C, Craciunescu F, Yang J, Chiu P, Fromme P, et al.
Sci Rep
. 2020 Mar;
10(1):4163.
PMID: 32123280
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Robertson K, Truong C, Craciunescu F, Yang J, Chiu P, Fromme P, et al.
Sci Rep
. 2019 Nov;
9(1):17606.
PMID: 31772280
Membrane-embedded proteins are critical to the establishment, survival and persistence in the host of the Lyme disease bacterium Borrelia burgdorferi (Bb), but to date, there are no solved structures of...
10.
Hansen D, Craciunescu F, Fromme P, Johnston S, Sykes K
Curr Protoc Protein Sci
. 2018 Mar;
91:29.20.1-29.20.22.
PMID: 29516482
Membrane proteins are the molecular interface of the cell and its environs; however, studies of membrane proteins are highly technically challenging, mainly due to instability of the isolated protein. Towards...