Debra F Higgins
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Explore the profile of Debra F Higgins including associated specialties, affiliations and a list of published articles.
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16
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1256
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Recent Articles
1.
Krzyzanowska A, Higgins D, Barron S, Loughman T, ONeill A, Sheehan K, et al.
BJUI Compass
. 2025 Jan;
6(1):e474.
PMID: 39877562
Objectives: This study aimed to clinically validate the six-gene prognostic molecular clinical risk score (MCRS) for the prediction of aggressive prostate cancer in diagnostic biopsy tissue. Methods: MCRS was evaluated...
2.
Krzyzanowska A, Barron S, Higgins D, Loughman T, ONeill A, Sheehan K, et al.
Eur Urol Focus
. 2023 Apr;
9(6):983-991.
PMID: 37105783
Background: Molecular signatures in prostate cancer (PCa) tissue can provide useful prognostic information to improve the understanding of a patient's risk of harbouring aggressive disease. Objective: To develop and validate...
3.
Higgins D, Ewart L, Masterson E, Tennant S, Grebnev G, Prunotto M, et al.
Biochim Biophys Acta Mol Basis Dis
. 2017 Sep;
1863(12):3095-3104.
PMID: 28923783
Bone morphogenetic protein-7 (BMP-7) counteracts pro-fibrotic effects of TGFβ in cultured renal cells and protects from fibrosis in acute and chronic renal injury models. Using the unilateral ureteral obstruction (UUO)...
4.
Scully D, Keane E, Batt E, Karunakaran P, Higgins D, Itasaki N
Development
. 2016 May;
143(10):1742-52.
PMID: 27190038
Hypoxia is encountered in either pathological or physiological conditions, the latter of which is seen in amniote embryos prior to the commencement of a functional blood circulation. During the hypoxic...
5.
Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, et al.
Am J Physiol Renal Physiol
. 2016 Apr;
311(1):F35-45.
PMID: 27122540
Diabetic nephropathy is the most common microvascular complication of diabetes mellitus, manifesting as mesangial expansion, glomerular basement membrane thickening, glomerular sclerosis, and progressive tubulointerstitial fibrosis leading to end-stage renal disease....
6.
7.
Corcoran J, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Borgeson E, et al.
Biochim Biophys Acta
. 2013 Apr;
1833(8):1969-78.
PMID: 23567938
TGF-β1 is a prototypic profibrotic cytokine and major driver of fibrosis in the kidney and other organs. Induced in high glucose-1 (IHG-1) is a mitochondrial protein which we have recently...
8.
Brennan E, Nolan K, Borgeson E, Gough O, McEvoy C, Docherty N, et al.
J Am Soc Nephrol
. 2013 Mar;
24(4):627-37.
PMID: 23520204
Lipoxins, which are endogenously produced lipid mediators, promote the resolution of inflammation, and may inhibit fibrosis, suggesting a possible role in modulating renal disease. Here, lipoxin A4 (LXA4) attenuated TGF-β1-induced...
9.
Borgeson E, McGillicuddy F, Harford K, Corrigan N, Higgins D, Maderna P, et al.
FASEB J
. 2012 Jun;
26(10):4287-94.
PMID: 22700871
Aging and adiposity are associated with chronic low-grade inflammation, which underlies the development of obesity-associated complications, including type 2 diabetes mellitus (T2DM). The mechanisms underlying adipose inflammation may include macrophage...
10.
Borgeson E, Docherty N, Murphy M, Rodgers K, Ryan A, OSullivan T, et al.
FASEB J
. 2011 Jun;
25(9):2967-79.
PMID: 21628447
Unresolved inflammation underlies the development of fibrosis and organ failure. Here, we investigate the potential of the proresolving eicosanoid lipoxinA₄ (LXA₄) and its synthetic analog benzo-LXA₄ to prophylactically modulate fibrotic...