Deborah R Boone
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Explore the profile of Deborah R Boone including associated specialties, affiliations and a list of published articles.
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12
Citations
180
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Recent Articles
1.
Weisz H, Boone D, Coggins W, Edwards G, Willey H, Widen S, et al.
PLoS One
. 2022 Jun;
17(6):e0267682.
PMID: 35657963
Evaluating novel compounds for neuroprotective effects in animal models of traumatic brain injury (TBI) is a protracted, labor-intensive and costly effort. However, the present lack of effective treatment options for...
2.
Sell S, Boone D, Weisz H, Cardenas C, Willey H, Bolding I, et al.
PLoS One
. 2019 Aug;
14(8):e0221163.
PMID: 31442236
Patients with traumatic brain injury (TBI) are frequently diagnosed with depression. Together, these two leading causes of death and disability significantly contribute to the global burden of healthcare costs. However,...
3.
Boone D, Weisz H, Willey H, Torres K, Falduto M, Sinha M, et al.
PLoS One
. 2019 Apr;
14(4):e0214741.
PMID: 30943276
There are no existing treatments for the long-term degenerative effects of traumatic brain injury (TBI). This is due, in part, to our limited understanding of chronic TBI and uncertainty about...
4.
Boone D, Weisz H, Sell S, Hellmich H
Methods Mol Biol
. 2018 Jan;
1723:235-245.
PMID: 29344864
The methods presented here are based on our laboratory's 15 years of experience using laser capture microdissection to obtain samples for the study of gene expression after traumatic brain injury...
5.
Boone D, Leek J, Falduto M, Torres K, Sell S, Parsley M, et al.
PLoS One
. 2017 Oct;
12(10):e0185943.
PMID: 29016640
Virally mediated RNA interference (RNAi) to knock down injury-induced genes could improve functional outcome after traumatic brain injury (TBI); however, little is known about the consequences of gene knockdown on...
6.
Weisz H, Boone D, Sell S, Hellmich H
J Vis Exp
. 2017 Sep;
(127).
PMID: 28930995
The ability to isolate specific brain regions of interest can be impeded in tissue disassociation techniques that do not preserve their spatial distribution. Such techniques also potentially skew gene expression...
7.
Boone D, Micci M, Taglialatela I, Hellmich J, Weisz H, Bi M, et al.
PLoS One
. 2015 May;
10(5):e0127287.
PMID: 26016641
Cognitive deficits in survivors of traumatic brain injury (TBI) are associated with irreversible neurodegeneration in brain regions such as the hippocampus. Comparative gene expression analysis of dying and surviving neurons...
8.
Boone D, Sell S, Hellmich H
J Vis Exp
. 2013 Apr;
(74).
PMID: 23603738
Long-term cognitive disability after TBI is associated with injury-induced neurodegeneration in the hippocampus-a region in the medial temporal lobe that is critical for learning, memory and executive function. Hence our...
9.
Hellmich H, Rojo D, Micci M, Sell S, Boone D, Crookshanks J, et al.
PLoS One
. 2013 Jan;
8(1):e53230.
PMID: 23326402
Developing new pharmacotherapies for traumatic brain injury (TBI) requires elucidation of the neuroprotective mechanisms of many structurally and functionally diverse compounds. To test our hypothesis that diverse neuroprotective drugs similarly...
10.
Boone D, Sell S, Micci M, Crookshanks J, Parsley M, Uchida T, et al.
PLoS One
. 2012 Oct;
7(10):e46204.
PMID: 23056261
Circadian rhythm disturbances are frequently reported in patients recovering from traumatic brain injury (TBI). Since circadian clock output is mediated by some of the same molecular signaling cascades that regulate...