Deborah C Otteson
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Explore the profile of Deborah C Otteson including associated specialties, affiliations and a list of published articles.
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27
Citations
484
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Recent Articles
1.
Webster S, Sklar N, Spitsbergen J, Stanchfield M, Webster M, Linn D, et al.
Exp Eye Res
. 2021 Aug;
210:108717.
PMID: 34348130
The adult mammal lacks the ability to regenerate neurons lost to retinal damage or disease in a meaningful capacity. However, previous studies from this laboratory have demonstrated that PNU-282987, an...
2.
Webster M, Barnett B, Stanchfield M, Paris J, Webster S, Cooley-Themm C, et al.
Invest Ophthalmol Vis Sci
. 2019 Feb;
60(2):570-579.
PMID: 30721274
Purpose: The adult mammalian retina is typically incapable of regeneration when damaged by disease or trauma. Restoration of function would require generation of new adult neurons, something that until recently,...
3.
Saha A, Tiwari S, Dharmarajan S, Otteson D, Belecky-Adams T
Gene Expr Patterns
. 2018 Sep;
30:37-48.
PMID: 30179675
Background: The acetylation state of histones has been used as an indicator of the developmental state of progenitor and differentiating cells. The goal of this study was to determine the...
4.
Manarang J, Otteson D, McDermott A
Curr Eye Res
. 2017 Sep;
42(11):1474-1481.
PMID: 28910167
Aims: Antimicrobial peptides (AMPs) have been implicated in the pathogenesis of several cancers, although there is also evidence suggesting potential for novel, AMP-based antitumor therapies. Discerning potential roles of AMPs...
5.
Beach K, Wang J, Otteson D
Stem Cells Int
. 2017 Feb;
2017:1610691.
PMID: 28194183
In humans and other mammals, the neural retina does not spontaneously regenerate, and damage to the retina that kills retinal neurons results in permanent blindness. In contrast to embryonic stem...
6.
Otteson D
Neuroscience
. 2017 Jan;
346:447-449.
PMID: 28131621
World-wide, two degenerative retinal diseases, glaucoma and age-related macular degeneration, are estimated to affect more than 12% of individuals over the age of 40 (Tham et al., 2014; Wong et...
7.
Wang J, Galvao J, Beach K, Luo W, Urrutia R, Goldberg J, et al.
J Biol Chem
. 2016 Nov;
291(41):21422.
PMID: 27825077
No abstract available.
8.
Wang J, Galvao J, Beach K, Luo W, Urrutia R, Goldberg J, et al.
J Biol Chem
. 2016 Jul;
291(35):18084-95.
PMID: 27402841
Regenerative medicine holds great promise for the treatment of degenerative retinal disorders. Krüppel-like factors (KLFs) are transcription factors that have recently emerged as key tools in regenerative medicine because some...
9.
Adhikari A, Geranpayeh T, Chu W, Otteson D
Mater Sci Eng C Mater Biol Appl
. 2015 Dec;
60:151-155.
PMID: 26706518
In this report, the effects of argon (Ar) ion irradiation on poly(lactic acid-co-glycolic acid) (PLGA) substrates on biocompatibility were studied. PLGA scaffold substrates were prepared by spin coating glass surfaces...
10.
Tiwari S, Dharmarajan S, Shivanna M, Otteson D, Belecky-Adams T
BMC Dev Biol
. 2014 Jul;
14:30.
PMID: 25011550
Background: Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression...