Debashree Basudhar
Overview
Explore the profile of Debashree Basudhar including associated specialties, affiliations and a list of published articles.
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21
Citations
450
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Recent Articles
11.
Frank D, Zhao Y, Wong S, Basudhar D, De Voss J, de Montellano P
J Biol Chem
. 2016 Feb;
291(14):7325-33.
PMID: 26833565
Cholest-4-en-3-one, whether added exogenously or generated intracellularly from cholesterol, inhibits the growth ofMycobacterium tuberculosiswhen CYP125A1 and CYP142A1, the cytochrome P450 enzymes that initiate degradation of the sterol side chain, are...
12.
Basudhar D, Ridnour L, Cheng R, Kesarwala A, Heinecke J, Wink D
Coord Chem Rev
. 2015 Dec;
306(Pt 2):708-723.
PMID: 26688591
Small redox active molecules such as reactive nitrogen and oxygen species and hydrogen sulfide have emerged as important biological mediators that are involved in various physiological and pathophysiological processes. Advancement...
13.
Ridnour L, Cheng R, Weiss J, Kaur S, Soto-Pantoja D, Basudhar D, et al.
Cancer Res
. 2015 May;
75(14):2788-99.
PMID: 25990221
Nitric oxide synthases (NOS) are important mediators of progrowth signaling in tumor cells, as they regulate angiogenesis, immune response, and immune-mediated wound healing. Ionizing radiation (IR) is also an immune...
14.
Basudhar D, Madrona Y, Kandel S, Lampe J, Nishida C, de Montellano P
J Biol Chem
. 2015 Feb;
290(16):10000-17.
PMID: 25670859
Defining the conformational states of cytochrome P450 active sites is critical for the design of agents that minimize drug-drug interactions, the development of isoform-specific P450 inhibitors, and the engineering of...
15.
Basudhar D, Cheng R, Bharadwaj G, Ridnour L, Wink D, Miranda K
Free Radic Biol Med
. 2015 Feb;
83:101-14.
PMID: 25659932
Diazeniumdiolate-based aspirin prodrugs have previously been shown to retain the anti-inflammatory properties of aspirin while protecting against the common side effect of stomach ulceration. Initial analysis of two new prodrugs...
16.
Bharadwaj G, Benini P, Basudhar D, Ramos-Colon C, Johnson G, Larriva M, et al.
Nitric Oxide
. 2014 Sep;
42:70-8.
PMID: 25192820
Nitroxyl (HNO) donors have been shown to elicit a variety of pharmacological responses, ranging from tumoricidal effects to treatment of heart failure. Isopropylamine-based diazeniumdiolates have been shown to produce HNO...
17.
Cheng R, Basudhar D, Ridnour L, Heinecke J, Kesarwala A, Glynn S, et al.
Nitric Oxide
. 2014 Aug;
43:17-28.
PMID: 25153034
Nitric oxide (NO) synthase 2 (NOS2), a major inflammatory protein, modulates disease progression via NO in a number of pathologies, including cancer. The role of NOS2-derived NO is not only...
18.
Basudhar D, Bharadwaj G, Cheng R, Jain S, Shi S, Heinecke J, et al.
J Med Chem
. 2013 Oct;
56(20):7804-20.
PMID: 24102516
Structural modifications of nonsteroidal anti-inflammatory drugs (NSAIDs) have successfully reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory activity, but they may increase the risk of myocardial infarction with...
19.
Flores-Santana W, Salmon D, Donzelli S, Switzer C, Basudhar D, Ridnour L, et al.
Antioxid Redox Signal
. 2011 Jan;
14(9):1659-74.
PMID: 21235346
The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While...
20.
Flores-Santana W, Switzer C, Ridnour L, Basudhar D, Mancardi D, Donzelli S, et al.
Arch Pharm Res
. 2009 Sep;
32(8):1139-53.
PMID: 19727606
For the past couple of decades nitric oxide (NO) and nitroxyl (HNO) have been extensively studied due to the important role they play in many physiological and/or pharmacological processes. Many...