Dean W Roberts
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Explore the profile of Dean W Roberts including associated specialties, affiliations and a list of published articles.
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16
Citations
711
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Recent Articles
1.
James L, McGill M, Roberts D, Hinson J, Lee W
Adv Clin Chem
. 2020 Jun;
98:35-50.
PMID: 32564787
Acetaminophen liver injury is the most common cause of acute liver injury in the United States and several other countries. Diagnosis of acetaminophen-induced acute liver injury in the clinic is...
2.
Roberts D, Lee W, Hinson J, Bai S, Swearingen C, Stravitz R, et al.
Clin Gastroenterol Hepatol
. 2016 Sep;
15(4):555-562.e3.
PMID: 27641661
Background & Aims: A rapid and reliable point-of-care assay to detect acetaminophen protein adducts in the serum of patients with acute liver injury could improve diagnosis and management. AcetaSTAT is...
3.
Hartman J, Letzig L, Roberts D, James L, Fifer E, Miller G
Biochem Pharmacol
. 2015 Jul;
97(3):341-9.
PMID: 26225832
Risk assessment for exposure to mixtures of drugs and pollutants relies heavily on in vitro characterization of their bioactivation and/or metabolism individually and extrapolation to mixtures assuming no interaction. Herein,...
4.
Yang X, Greenhaw J, Shi Q, Roberts D, Hinson J, Muskhelishvili L, et al.
J Pharmacol Exp Ther
. 2012 Oct;
344(1):286-94.
PMID: 23093024
Acetaminophen (APAP)-induced liver injury is the leading cause of acute liver failure in many countries. This study determined the extent of liver protein sulfhydryl depletion not only in whole liver...
5.
Yang X, Greenhaw J, Ali A, Shi Q, Roberts D, Hinson J, et al.
J Pharmacol Exp Ther
. 2011 Nov;
340(2):360-8.
PMID: 22045778
The role of protein glutathionylation in acetaminophen (APAP)-induced liver injury was investigated in this study. A single oral gavage dose of 150 or 300 mg/kg APAP in B6C3F1 mice produced...
6.
Mercer K, Apostolov E, Gamboa da Costa G, Yu X, Lang P, Roberts D, et al.
Int J Mol Epidemiol Genet
. 2011 May;
1(2):92-103.
PMID: 21537383
Previously, we reported a strong association of the high activity SULT1A1*1 allele and overall survival of patients receiving tamoxifen therapy, indicating that sulfation of 4-hydroxytamoxifen (4-OHT) via SULT1A1 may contribute...
7.
Zhou X, Wei Y, Xie F, Laukaitis C, Karn R, Kluetzman K, et al.
Mol Pharmacol
. 2011 Jan;
79(4):710-23.
PMID: 21252290
To identify novel factors or mechanisms that are important for the resistance of tissues to chemical toxicity, we have determined the mechanisms underlying the previously observed increases in resistance to...
8.
Agarwal R, MacMillan-Crow L, Rafferty T, Saba H, Roberts D, Fifer E, et al.
J Pharmacol Exp Ther
. 2011 Jan;
337(1):110-6.
PMID: 21205919
In overdose the analgesic/antipyretic acetaminophen (APAP) is hepatotoxic. Toxicity is mediated by initial hepatic metabolism to N-acetyl-p-benzoquinone imine (NAPQI). After low doses NAPQI is efficiently detoxified by GSH. However, in...
9.
Hinson J, Roberts D, James L
Handb Exp Pharmacol
. 2009 Dec;
(196):369-405.
PMID: 20020268
Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal. Acetaminophen poisoning accounts for approximately one-half of all cases of acute...
10.
Gopee N, Roberts D, Webb P, Cozart C, Siitonen P, Latendresse J, et al.
Toxicol Sci
. 2009 Jul;
111(1):37-48.
PMID: 19574408
Many cosmetics, sunscreens, and other consumer products are reported to contain nanoscale materials. The possible transdermal absorption of nanoscale materials and the long-term consequences of the absorption have not been...