Dean C Pask
Overview
Explore the profile of Dean C Pask including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
334
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0
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Recent Articles
1.
Williams M, Wang X, Bastos H, Grondys-Kotarba G, Wu Q, Jin S, et al.
Blood Adv
. 2024 Oct;
9(2):291-309.
PMID: 39374575
Adult hematopoietic stem cells (HSCs) are responsible for the lifelong production of blood and immune cells, a process regulated by extracellular cues, including cytokines. Many cytokines signal through the conserved...
2.
Li J, Williams M, Park H, Bastos H, Wang X, Prins D, et al.
Blood
. 2022 Jun;
140(14):1592-1606.
PMID: 35767701
Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal downstream mediator of...
3.
Shepherd M, Li J, Wilson N, Oedekoven C, Li J, Belmonte M, et al.
Blood
. 2018 Jul;
132(8):791-803.
PMID: 29991556
Recent advances in single-cell technologies have permitted the investigation of heterogeneous cell populations at previously unattainable resolution. Here we apply such approaches to resolve the molecular mechanisms driving disease in...
4.
Li J, Prins D, Park H, Grinfeld J, Gonzalez-Arias C, Loughran S, et al.
Blood
. 2017 Dec;
131(6):649-661.
PMID: 29282219
Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). Multiple different mutations have been reported,...
5.
Moreau T, Evans A, Vasquez L, Tijssen M, Yan Y, Trotter M, et al.
Nat Commun
. 2017 Jul;
8:15076.
PMID: 28752836
This corrects the article DOI: 10.1038/ncomms11208.
6.
Kirschner K, Chandra T, Kiselev V, Flores-Santa Cruz D, Macaulay I, Park H, et al.
Cell Rep
. 2017 May;
19(8):1503-1511.
PMID: 28538171
Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown. Using single-cell transcriptomics, we...
7.
Moreau T, Evans A, Vasquez L, Tijssen M, Yan Y, Trotter M, et al.
Nat Commun
. 2016 Apr;
7:11208.
PMID: 27052461
The production of megakaryocytes (MKs)--the precursors of blood platelets--from human pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine. Here we describe an original approach for the large-scale...
8.
Li J, Kent D, Godfrey A, Manning H, Nangalia J, Aziz A, et al.
Blood
. 2014 Apr;
123(20):3139-51.
PMID: 24692758
Genomic regions of acquired uniparental disomy (UPD) are common in malignancy and frequently harbor mutated oncogenes. Homozygosity for such gain-of-function mutations is thought to modulate tumor phenotype, but direct evidence...
9.
Kent D, Li J, Tanna H, Fink J, Kirschner K, Pask D, et al.
PLoS Biol
. 2013 Jun;
11(6):e1001576.
PMID: 23750118
Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to understand how single stem cells are subverted to cause...