De-En Xu
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Explore the profile of De-En Xu including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
213
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Recent Articles
1.
Chen H, Yang G, Xu D, Du Y, Zhu C, Hu H, et al.
Neurosci Bull
. 2024 Dec;
41(3):547-548.
PMID: 39643774
No abstract available.
2.
Chen H, Yang G, Xu D, Du Y, Zhu C, Hu H, et al.
Neurosci Bull
. 2024 Sep;
41(3):374-390.
PMID: 39283565
Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the quality of organelles...
3.
Zou Y, Zhang X, Chen X, Ma X, Feng X, Sun Y, et al.
Mol Neurobiol
. 2024 Aug;
62(3):2764-2780.
PMID: 39164481
Contactin-associated protein1 (Caspr1) plays an important role in the formation and stability of myelinated axons. In Caspr1 mutant mice, autophagy-related structures accumulate in neurons, causing axonal degeneration; however, the mechanism...
4.
Liu J, Zhao X, Wu M, Shi Y, Huang Z, Fang L, et al.
Cell Death Dis
. 2024 Aug;
15(8):591.
PMID: 39143050
Neurons rely heavily on high mitochondrial metabolism to provide sufficient energy for proper development. However, it remains unclear how neurons maintain high oxidative phosphorylation (OXPHOS) during development. Mitophagy plays a...
5.
Zhao X, Xu D, Wu M, Liu J, Shi Z, Ma Q
Neural Regen Res
. 2024 May;
20(1):6-20.
PMID: 38767472
The endoplasmic reticulum, a key cellular organelle, regulates a wide variety of cellular activities. Endoplasmic reticulum autophagy, one of the quality control systems of the endoplasmic reticulum, plays a pivotal...
6.
Hu Y, Yang G, Liang X, Ding X, Xu D, Li Z, et al.
Front Neurol
. 2023 Mar;
14:1117188.
PMID: 36970512
Transcranial ultrasound stimulation is a neurostimulation technique that has gradually attracted the attention of researchers, especially as a potential therapy for neurological disorders, because of its high spatial resolution, its...
7.
Yuan D, Yang G, Wu W, Li Q, Xu D, Ntim M, et al.
Aging Cell
. 2022 Mar;
21(5):e13593.
PMID: 35353937
Aberrant increases in neuronal network excitability may contribute to cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability of neurons are not fully understood. Voltage-gated sodium channels (VGSC...
8.
Sun Y, Chen W, Huang Z, Yang G, Wu M, Xu D, et al.
Cells
. 2022 Feb;
11(3).
PMID: 35159260
Excitatory-inhibitory imbalance (E/I) is a fundamental mechanism underlying autism spectrum disorders (ASD). TRIM32 is a risk gene genetically associated with ASD. The absence of TRIM32 causes impaired generation of inhibitory...
9.
Xie Y, Pan T, Xu D, Huang X, Tang Y, Huang W, et al.
Front Cell Dev Biol
. 2021 Nov;
9:733945.
PMID: 34746130
Disrupted myelin and impaired myelin repair have been observed in the brains of patients and various mouse models of Alzheimer's disease (AD). Clemastine, an H1-antihistamine, shows the capability to induce...
10.
Li Z, Chen L, Zhao X, Chen H, Sun Y, Lu M, et al.
Exp Neurol
. 2021 May;
342:113742.
PMID: 33965410
Alzheimer's disease (AD) is a neurodegenerative disorder with limited available drugs for treatment. Enhancing autophagy attenuates AD pathology in various AD model mice. Thus, development of potential drugs which enhance...