Dawn M Wenzel
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Explore the profile of Dawn M Wenzel including associated specialties, affiliations and a list of published articles.
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10
Citations
639
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Recent Articles
1.
Wenzel D, Olivier-Van Stichelen S
Biochem Soc Trans
. 2022 Nov;
50(6):1693-1702.
PMID: 36383066
Proper neuronal development is essential to growth and adult brain function. Alterations at any step of this highly organized sequence of events, due to genetic mutations or environmental factors, triggers...
2.
Wenzel D, Mackay D, Skalicky J, Paine E, Miller M, Ullman K, et al.
Elife
. 2022 Sep;
11.
PMID: 36107470
The 12 related human ESCRT-III proteins form filaments that constrict membranes and mediate fission, including during cytokinetic abscission. The C-terminal tails of polymerized ESCRT-III subunits also bind proteins that contain...
3.
Sadler J, Wenzel D, Strohacker L, Guindo-Martinez M, Alam S, Mercader J, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(38):E8900-E8908.
PMID: 30181294
Cytokinetic abscission facilitates the irreversible separation of daughter cells. This process requires the endosomal-sorting complexes required for transport (ESCRT) machinery and is tightly regulated by charged multivesicular body protein 4C...
4.
Caballe A, Wenzel D, Agromayor M, Alam S, Skalicky J, Kloc M, et al.
Elife
. 2015 May;
4:e06547.
PMID: 26011858
The endosomal sorting complexes required for transport (ESCRT) machinery mediates the physical separation between daughter cells during cytokinetic abscission. This process is regulated by the abscission checkpoint, a genome protection...
5.
Vittal V, Shi L, Wenzel D, Scaglione K, Duncan E, Basrur V, et al.
Nat Chem Biol
. 2014 Dec;
11(1):83-9.
PMID: 25436519
Ubiquitination of the αN-terminus of protein substrates has been reported sporadically since the early 1980s. However, the identity of an enzyme responsible for this unique ubiquitin (Ub) modification has only...
6.
Vittal V, Wenzel D, Brzovic P, Klevit R
Cell Biochem Biophys
. 2013 May;
67(1):103-10.
PMID: 23709311
The biochemical and structural characterization of ubiquitin-conjugating enzymes (E2s) over the past 30 years has fostered important insights into ubiquitin transfer mechanisms. Although many of these enzymes share high sequence...
7.
Skalicky J, Arii J, Wenzel D, Stubblefield W, Katsuyama A, Uter N, et al.
J Biol Chem
. 2012 Oct;
287(52):43910-26.
PMID: 23105106
The endosomal sorting complex required for transport (ESCRT) pathway remodels membranes during multivesicular body biogenesis, the abscission stage of cytokinesis, and enveloped virus budding. The ESCRT-III and VPS4 ATPase complexes...
8.
Wenzel D, Klevit R
BMC Biol
. 2012 Mar;
10:24.
PMID: 22420831
Ubiquitin signaling pathways rely on E3 ligases for effecting the final transfer of ubiquitin from E2 ubiquitin conjugating enzymes to a protein target. Here we re-evaluate the hybrid RING/HECT mechanism...
9.
Wenzel D, Lissounov A, Brzovic P, Klevit R
Nature
. 2011 May;
474(7349):105-8.
PMID: 21532592
Although the functional interaction between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s) is essential in ubiquitin (Ub) signalling, the criteria that define an active E2-E3 pair are not well established....
10.
Wenzel D, Stoll K, Klevit R
Biochem J
. 2010 Dec;
433(1):31-42.
PMID: 21158740
Ubiquitination is a post-translational modification pathway involved in myriad cellular regulation and disease pathways. The Ub (ubiquitin) transfer cascade requires three enzyme activities: a Ub-activating (E1) enzyme, a Ub-conjugating (E2)...