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Dawn C Harper

Explore the profile of Dawn C Harper including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 644
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Recent Articles
1.
Bi H, Tranell J, Harper D, Lin W, Li J, Hellstrom A, et al.
PLoS Genet . 2023 Apr; 19(4):e1010724. PMID: 37068079
The biochemical pathway regulating the synthesis of yellow/red pheomelanin is less well characterized than the synthesis of black/brown eumelanin. Inhibitor of gold (IG phenotype) is a plumage colour variant in...
2.
Puckett E, Davis I, Harper D, Wakamatsu K, Battu G, Belant J, et al.
Curr Biol . 2022 Dec; 33(1):86-97.e10. PMID: 36528024
Color variation is a frequent evolutionary substrate for camouflage in small mammals, but the underlying genetics and evolutionary forces that drive color variation in natural populations of large mammals are...
3.
Bowman S, Le L, Zhu Y, Harper D, Sitaram A, Theos A, et al.
J Cell Biol . 2021 Apr; 220(7). PMID: 33886957
Membrane transport carriers fuse with target membranes through engagement of cognate vSNAREs and tSNAREs on each membrane. How vSNAREs are sorted into transport carriers is incompletely understood. Here we show...
4.
Benito-Martinez S, Zhu Y, Jani R, Harper D, Marks M, Delevoye C
J Invest Dermatol . 2020 Jan; 140(2):257-268.e8. PMID: 31980058
Pigmentation of the skin and hair represents the result of melanin biosynthesis within melanosomes of epidermal melanocytes, followed by the transfer of mature melanin granules to adjacent keratinocytes within the...
5.
Wang Y, Hayes V, Jarocha D, Sim X, Harper D, Fuentes R, et al.
Blood . 2015 Apr; 125(23):3627-36. PMID: 25852052
Thrombopoiesis is the process by which megakaryocytes release platelets that circulate as uniform small, disc-shaped anucleate cytoplasmic fragments with critical roles in hemostasis and related biology. The exact mechanism of...
6.
Meng R, Wu J, Harper D, Wang Y, Kowalska M, Abrams C, et al.
Blood . 2014 Dec; 125(10):1623-32. PMID: 25477496
Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, bleeding diathesis, and other variable symptoms. The bleeding diathesis has been attributed to δ storage pool deficiency, reflecting the malformation of platelet...
7.
Theos A, Watt B, Harper D, Janczura K, Theos S, Herman K, et al.
Pigment Cell Melanoma Res . 2013 Mar; 26(4):470-86. PMID: 23452376
Proteolytic fragments of the pigment cell-specific glycoprotein, PMEL, form the amyloid fibrillar matrix underlying melanins in melanosomes. The fibrils form within multivesicular endosomes to which PMEL is selectively sorted and...
8.
Meng R, Wang Y, Yao Y, Zhang Z, Harper D, Heijnen H, et al.
Blood . 2012 May; 120(2):404-14. PMID: 22611153
Platelet dense granules are members of a family of tissue-specific, lysosome-related organelles that also includes melanosomes in melanocytes. Contents released from dense granules after platelet activation promote coagulation and hemostasis,...
9.
Truschel S, Simoes S, Setty S, Harper D, Tenza D, Thomas P, et al.
Traffic . 2009 Jul; 10(9):1318-36. PMID: 19624486
Melanosomes are lysosome-related organelles that coexist with lysosomes within melanocytes. The pathways by which melanosomal proteins are diverted from endocytic organelles toward melanosomes are incompletely defined. In melanocytes from mouse...
10.
Damek-Poprawa M, Diemer T, Lopes V, Lillo C, Harper D, Marks M, et al.
J Biol Chem . 2009 Feb; 284(16):10877-89. PMID: 19240024
Melanoregulin (MREG), the product of the Mreg(dsu) gene, is a small highly charged protein, hypothesized to play a role in organelle biogenesis due to its effect on pigmentation in dilute,...