Dawid Jaslan
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Explore the profile of Dawid Jaslan including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
104
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Recent Articles
1.
Chi G, Jaslan D, Kudrina V, Bock J, Li H, Pike A, et al.
Structure
. 2024 May;
32(8):1137-1149.e4.
PMID: 38815576
Two pore channels are lysosomal cation channels with crucial roles in tumor angiogenesis and viral release from endosomes. Inhibition of the two-pore channel 2 (TPC2) has emerged as potential therapeutic...
2.
Reyer A, Bazihizina N, Jaslan J, Scherzer S, Schafer N, Jaslan D, et al.
Plant J
. 2024 Apr;
118(6):2219-2232.
PMID: 38602250
Sugar beet (Beta vulgaris) is the major sugar-producing crop in Europe and Northern America, as the taproot stores sucrose at a concentration of around 20%. Genome sequence analysis together with...
3.
Yuan Y, Jaslan D, Rahman T, Bracher F, Grimm C, Patel S
J Physiol
. 2024 Apr;
602(8):1623-1636.
PMID: 38598430
Two-pore channels and TRP mucolipins are ubiquitous endo-lysosomal cation channels of pathophysiological relevance. Both are Ca-permeable and regulated by phosphoinositides, principally PI(3,5)P. Accumulating evidence has uncovered synergistic channel activation by...
4.
Tsvilovskyy V, Ottenheijm R, Kriebs U, Schutz A, Diakopoulos K, Jha A, et al.
J Clin Invest
. 2024 Apr;
134(7).
PMID: 38557489
Regulated exocytosis is initiated by increased Ca2+ concentrations in close spatial proximity to secretory granules, which is effectively prevented when the cell is at rest. Here we showed that exocytosis...
5.
Lu J, Dreyer I, Dickinson M, Panzer S, Jaslan D, Navarro-Retamal C, et al.
Elife
. 2023 Nov;
12.
PMID: 37991833
To fire action-potential-like electrical signals, the vacuole membrane requires the two-pore channel TPC1, formerly called SV channel. The TPC1/SV channel functions as a depolarization-stimulated, non-selective cation channel that is inhibited...
6.
Xu M, Zhong X, Huang P, Jaslan D, Wang P, Sun X, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(34):e2215777120.
PMID: 37585464
TRPML3 is a Ca/Na release channel residing in both phagophores and endolysosomal membranes. It is activated by PI3P and PI3,5P2. Its activity can be enhanced by high luminal pH and...
7.
Jaslan D, Patel S, Grimm C
Cell Calcium
. 2023 Apr;
112:102732.
PMID: 37031661
No abstract available.
8.
Jaslan D, Ferro I, Kudrina V, Yuan Y, Patel S, Grimm C
Cell Calcium
. 2022 Dec;
109:102675.
PMID: 36525777
NAADP (nicotinic acid adenine dinucleotide phosphate) is a second messenger, releasing Ca from acidic calcium stores such as endosomes and lysosomes. PI(3,5)P (phosphatidylinositol 3,5-bisphosphate) is a phospho-inositide, residing on endolysosomal...
9.
Prat Castro S, Kudrina V, Jaslan D, Bock J, Rosato A, Grimm C
Cells
. 2022 Sep;
11(18).
PMID: 36139381
Lysosomal storage diseases (LSDs) resulting from inherited gene mutations constitute a family of disorders that disturb lysosomal degradative function leading to abnormal storage of macromolecular substrates. In most LSDs, central...
10.
Patel S, Yuan Y, Chen C, Jaslan D, Gunaratne G, Grimm C, et al.
Cells
. 2022 Aug;
11(15).
PMID: 35954212
Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels. Direct macroscopic recordings of recombinant TPCs...