David Z Qian
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Explore the profile of David Z Qian including associated specialties, affiliations and a list of published articles.
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39
Citations
2440
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Recent Articles
1.
Xue C, Ko H, Shi K, Pittsenbarger J, Dao L, Shi K, et al.
bioRxiv
. 2024 Nov;
PMID: 39484437
Summary: Single-cell RNA-Sequencing reveals heterogeneities of tumor cell populations. In most cases, however, the functional significance of the observed heterogeneity is not tested. In this study, we first identified a...
2.
Geng H, Ko H, Pittsenbarger J, Harvey C, Xue C, Liu Q, et al.
Front Cell Dev Biol
. 2021 Nov;
9:724059.
PMID: 34820369
Hypoxia is a universal pathological feature of solid tumors. Hypoxic tumor cells acquire metastatic and lethal phenotypes primarily through the activities of hypoxia-inducible factor 1 alpha (HIF1α). Therefore, HIF1α is...
3.
Sun D, Guan X, Moran A, Wu L, Qian D, Schedin P, et al.
Nat Biotechnol
. 2021 Nov;
40(4):527-538.
PMID: 34764492
Single-cell RNA sequencing (scRNA-seq) distinguishes cell types, states and lineages within the context of heterogeneous tissues. However, current single-cell data cannot directly link cell clusters with specific phenotypes. Here we...
4.
Kumar R, Mendonca J, Owoyemi O, Boyapati K, Thomas N, Kanacharoen S, et al.
Cancer Res
. 2021 Oct;
81(23):5948-5962.
PMID: 34645612
The discovery that androgens play an important role in the progression of prostate cancer led to the development of androgen deprivation therapy (ADT) as a first line of treatment. However,...
5.
Li Y, Sun X, Qian D, Dai M
Front Cell Dev Biol
. 2020 Nov;
8:590576.
PMID: 33251216
The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is overexpressed or deregulated in human cancers of diverse origins and plays a key role in...
6.
Geng H, Xue C, Mendonca J, Sun X, Liu Q, Reardon P, et al.
Nat Commun
. 2019 Jan;
10(1):164.
PMID: 30622254
The original version of this Article contained errors in Fig. 7. In panels e and f, the graph titles incorrectly read 'LNCaP-AdtNs' and 'LAPC4-AdtNs', respectively. These errors have now been...
7.
Geng H, Xue C, Mendonca J, Sun X, Liu Q, Reardon P, et al.
Nat Commun
. 2018 Nov;
9(1):4972.
PMID: 30478344
Despite recent advances, the efficacy of androgen/androgen receptor (AR)-targeted therapy remains limited for many patients with metastatic prostate cancer. This is in part because prostate cancers adaptively switch to the...
8.
Chen X, Zhao M, Huang J, Li Y, Wang S, Harrington C, et al.
J Cell Biochem
. 2018 Feb;
119(6):4945-4956.
PMID: 29384218
FOSL1 is frequently overexpressed in multiple types of human cancers including invasive breast cancers and implicated in cancer invasion and metastasis. However, how FOSL1 is overexpressed in cancers remains to...
9.
Li B, Gardner R, Xue C, Qian D, Xie F, Thomas G, et al.
Sci Rep
. 2016 Oct;
6:34513.
PMID: 27694829
cAMP-response element binding protein (CREB) is a nuclear transcription factor activated by multiple extracellular signals including growth factors and hormones. These extracellular cues activate CREB through phosphorylation at Ser133 by...
10.
Jiang K, Wang X, Geng H, Beer T, Qian D, Ramstrom O, et al.
Sci Lett J
. 2016 Apr;
4.
PMID: 27077134
Carbohydrate-conjugated fluorescent silica nanoprobes were prepared and used as a platform for galectin-1 and prostate cancer cell detection. The nanoparticles were efficiently conjugated using native, unprotected carbohydrate structures following a...