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David Yule

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Articles 11
Citations 373
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Recent Articles
1.
Loncke J, de Ridder I, Kale J, Wagner L, Kaasik A, Parys J, et al.
Biochim Biophys Acta Mol Cell Res . 2024 Oct; 1872(1):119857. PMID: 39370046
CISD2, a 2Fe2S cluster domain-containing protein, is implicated in Wolfram syndrome type 2, longevity and cancer. CISD2 is part of a ternary complex with IP receptors (IPRs) and anti-apoptotic BCL-2...
2.
Rugis J, Chaffer J, Sneyd J, Yule D
bioRxiv . 2023 Jul; PMID: 37398053
Calcium signaling data analysis has become increasing complex as the size of acquired datasets increases. In this paper we present a Ca signaling data analysis method that employs custom written...
3.
Su S, Rugis J, Wahl A, Doak S, Li Y, Suresh V, et al.
Bull Math Biol . 2022 Jul; 84(8):84. PMID: 35799078
Saliva is produced in two stages in the salivary glands: the secretion of primary saliva by the acinus and the modification of saliva composition to final saliva by the intercalated...
4.
Sneyd J, Crampin E, Yule D
Math Biosci . 2014 Jul; 257:69-79. PMID: 25014770
We review a multiscale model of saliva secretion, describing in brief how the model is constructed and what we have so far learned from it. The model begins at the...
5.
Park S, Shcheynikov N, Hong J, Zheng C, Suh S, Kawaai K, et al.
Gastroenterology . 2013 Apr; 145(1):232-241. PMID: 23542070
Background & Aims: The cyclic adenosine monophosphate (cAMP) and Ca(2+) signaling pathways synergize to regulate many physiological functions. However, little is known about the mechanisms by which these pathways interact....
6.
Siekmann I, Wagner 2nd L, Yule D, Crampin E, Sneyd J
Biophys J . 2012 Sep; 103(4):658-68. PMID: 22947927
Based upon an extensive single-channel data set, a Markov model for types I and II inositol trisphosphate receptors (IP(3)R) is developed. The model aims to represent accurately the kinetics of...
7.
Haun S, Sun L, Hubrack S, Yule D, Machaca K
Channels (Austin) . 2012 Aug; 6(5):379-84. PMID: 22878752
The Ins(1,4,5)P 3 receptor acts as a central hub for Ca ( 2+) signaling by integrating multiple signaling modalities into Ca ( 2+) release from intracellular stores downstream of G-protein...
8.
Siekmann I, Wagner 2nd L, Yule D, Fox C, Bryant D, Crampin E, et al.
Biophys J . 2011 Apr; 100(8):1919-29. PMID: 21504728
Ion channels are characterized by inherently stochastic behavior which can be represented by continuous-time Markov models (CTMM). Although methods for collecting data from single ion channels are available, translating a...
9.
Melvin J, Yule D, Shuttleworth T, Begenisich T
Annu Rev Physiol . 2005 Feb; 67:445-69. PMID: 15709965
The secretion of fluid and electrolytes by salivary gland acinar cells requires the coordinated regulation of multiple water and ion transporter and channel proteins. Notably, all the key transporter and...
10.
Basavappa S, Vulapalli S, Zhang H, Yule D, Coon S, Sundaram U
J Cell Physiol . 2004 Sep; 202(1):21-31. PMID: 15389550
Small intestinal crypt cells play a critical role in modulating Cl- secretion during digestion. The types of Cl- channels mediating Cl- secretion in the small intestine was investigated using the...