David Woolley
Overview
Explore the profile of David Woolley including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
177
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Recent Articles
1.
Bassan A, Steigerwalt R, Keller D, Beilke L, Bradley P, Bringezu F, et al.
Front Toxicol
. 2024 Apr;
6:1370045.
PMID: 38646442
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for...
2.
Keller D, Bassan A, Amberg A, Burns Naas L, Chambers J, Cross K, et al.
Front Toxicol
. 2023 Nov;
5:1234498.
PMID: 38026843
toxicology protocols are meant to support computationally-based assessments using principles that ensure that results can be generated, recorded, communicated, archived, and then evaluated in a uniform, consistent, and reproducible manner....
3.
Zwickl C, Graham J, Jolly R, Bassan A, Ahlberg E, Amberg A, et al.
Comput Toxicol
. 2023 Feb;
24.
PMID: 36818760
Acute models are being used to support an increasing number of application areas including (1) product research and development, (2) product approval and registration as well as (3) the transport,...
4.
Crofton K, Bassan A, Behl M, Chushak Y, Fritsche E, Gearhart J, et al.
Comput Toxicol
. 2022 Jul;
22.
PMID: 35844258
Neurotoxicology is the study of adverse effects on the structure or function of the developing or mature adult nervous system following exposure to chemical, biological, or physical agents. The development...
5.
Bassan A, Alves V, Amberg A, Anger L, Beilke L, Bender A, et al.
Comput Toxicol
. 2022 Jun;
20.
PMID: 35721273
The kidneys, heart and lungs are vital organ systems evaluated as part of acute or chronic toxicity assessments. New methodologies are being developed to predict these adverse effects based on...
6.
Tice R, Bassan A, Amberg A, Anger L, Beal M, Bellion P, et al.
Comput Toxicol
. 2022 Apr;
20.
PMID: 35368437
Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which require enormous resources in both money and time. models have been developed for predicting rodent carcinogens but have...
7.
Bassan A, Alves V, Amberg A, Anger L, Auerbach S, Beilke L, et al.
Comput Toxicol
. 2022 Mar;
20.
PMID: 35340402
Hepatotoxicity is one of the most frequently observed adverse effects resulting from exposure to a xenobiotic. For example, in pharmaceutical research and development it is one of the major reasons...
8.
Huynh E, Olinger A, Woolley D, Kaur Kohli R, Choczynski J, Davies J, et al.
Proc Natl Acad Sci U S A
. 2022 Jan;
119(4).
PMID: 35064080
The phase state of respiratory aerosols and droplets has been linked to the humidity-dependent survival of pathogens such as SARS-CoV-2. To inform strategies to mitigate the spread of infectious disease,...
9.
Johnson C, Ahlberg E, Anger L, Beilke L, Benigni R, Bercu J, et al.
Regul Toxicol Pharmacol
. 2020 Jul;
116:104688.
PMID: 32621976
The assessment of skin sensitization has evolved over the past few years to include in vitro assessments of key events along the adverse outcome pathway and opportunistically capitalize on the...
10.
Hasselgren C, Ahlberg E, Akahori Y, Amberg A, Anger L, Atienzar F, et al.
Regul Toxicol Pharmacol
. 2019 Jun;
107:104403.
PMID: 31195068
In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such methods is increasing in all applications but especially for regulatory submissions, such as for assessing chemicals...