Kevin P Cross
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Explore the profile of Kevin P Cross including associated specialties, affiliations and a list of published articles.
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36
Citations
381
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Recent Articles
1.
Faramarzi S, Bassan A, Cross K, Yang X, Myatt G, Volpe D, et al.
Front Pharmacol
. 2025 Feb;
15:1451164.
PMID: 40012840
The 2020 FDA drug-drug interaction (DDI) guidance includes a consideration for metabolites with structural alerts for potential mechanism-based inhibition (MBI) and describes how this information may be used to determine...
2.
Mou Z, Volarath P, Racz R, Cross K, Girireddy M, Chakravarti S, et al.
Chem Res Toxicol
. 2024 Nov;
37(12):1924-1933.
PMID: 39535830
Drug-induced cardiotoxicity represents one of the most common causes of attrition of drug candidates in preclinical and clinical development. For this reason, the evaluation of cardiac toxicity is essential during...
3.
Johnson C, Kiehl D, Christiaens P, Jodar F, Cuyvers R, Bassan A, et al.
PDA J Pharm Sci Technol
. 2024 Jun;
78(3):214-236.
PMID: 38942477
Leachables in pharmaceutical products may react with biomolecule active pharmaceutical ingredients (APIs), for example, monoclonal antibodies (mAb), peptides, and ribonucleic acids (RNA), potentially compromising product safety and efficacy or impacting...
4.
Cross K, Cook D, Scott S
eNeuro
. 2024 Jan;
11(2).
PMID: 38238081
An important aspect of motor function is our ability to rapidly generate goal-directed corrections for disturbances to the limb or behavioral goal. The primary motor cortex (M1) is a key...
5.
Cross K, DeMarini D
Mutat Res
. 2023 Oct;
827:111838.
PMID: 37804576
As part of an analysis performed under the auspices of the International Workshop on Genotoxicity Testing (IWGT) in 2017, we and others showed that Salmonella frameshift strain TA98 and base-substitution...
6.
Cross K, Guang H, Scott S
J Neurosci
. 2022 Dec;
43(5):787-802.
PMID: 36535766
A common problem in motor control concerns how to generate patterns of muscle activity when there are redundant solutions to attain a behavioral goal. Optimal feedback control is a theory...
7.
Faramarzi S, Kim M, Volpe D, Cross K, Chakravarti S, Stavitskaya L
Front Pharmacol
. 2022 Nov;
13:1040838.
PMID: 36339562
Assessing drug permeability across the blood-brain barrier (BBB) is important when evaluating the abuse potential of new pharmaceuticals as well as developing novel therapeutics that target central nervous system disorders....
8.
Johnson C, Anger L, Benigni R, Bower D, Bringezu F, Crofton K, et al.
Comput Toxicol
. 2022 Apr;
21.
PMID: 35368849
Understanding the reliability and relevance of a toxicological assessment is important for gauging the overall confidence and communicating the degree of uncertainty related to it. The process involved in assessing...
9.
Bassan A, Alves V, Amberg A, Anger L, Auerbach S, Beilke L, et al.
Comput Toxicol
. 2022 Mar;
20.
PMID: 35340402
Hepatotoxicity is one of the most frequently observed adverse effects resulting from exposure to a xenobiotic. For example, in pharmaceutical research and development it is one of the major reasons...
10.
Myatt G, Bassan A, Bower D, Johnson C, Miller S, Pavan M, et al.
Comput Toxicol
. 2022 Jan;
21.
PMID: 35036665
Mechanistically-driven alternative approaches to hazard assessment invariably require a battery of tests, including both models and experimental data. The decision-making process, from selection of the methods to combining the information...