David W Roberts
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Explore the profile of David W Roberts including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Nelms M, Lougee R, Roberts D, Richard A, Patlewicz G
Comput Toxicol
. 2023 Sep;
12:1-13.
PMID: 37701288
The molecular initiating event for many mechanisms of toxicological action comprise the reactive, covalent binding between an exogenous electrophile and an endogenous nucleophile. The target sites for electrophiles are typically...
12.
Roberts D, Kimber I, Basketter D
Regul Toxicol Pharmacol
. 2023 Apr;
141:105402.
PMID: 37116738
The local lymph node assay (LLNA) has provided a large dataset against which performance of non-animal approaches for prediction of skin sensitisation potential and potency can be assessed. However, a...
13.
Ahn J, Avonto C, Pandey P, Khan S, Khan I, Roberts D, et al.
Chem Res Toxicol
. 2023 Apr;
36(5):747-756.
PMID: 37042673
Structurally similar phytochemical compounds may elicit markedly different skin sensitization responses. Eugenol and isoeugenol are natural phenylpropanoids found in various essential oils are frequently used as fragrance ingredients in consumer...
14.
Marois M, Olson J, Wirth D, Elliott J, Fan X, Davis S, et al.
Commun Biol
. 2023 Mar;
6(1):341.
PMID: 36991092
Hyperspectral imaging and spectral analysis quantifies fluorophore concentration during fluorescence-guided surgery. However, acquisition of the multiple wavelengths required to implement these methods can be time-consuming and hinder surgical workflow. To...
15.
Roberts D, Basketter D
Regul Toxicol Pharmacol
. 2023 Mar;
140:105370.
PMID: 36898648
No abstract available.
16.
Roberts D
Crit Rev Toxicol
. 2022 Dec;
52(6):420-430.
PMID: 36542542
The direct peptide reactivity assay (DPRA) is an OECD test guideline method that aims to determine if a chemical is reactive enough to be a skin sensitiser. It involves incubation...
17.
Hartford A, Gill G, Ravi D, Tosteson T, Li Z, Russo G, et al.
Radiother Oncol
. 2022 Nov;
177:179-184.
PMID: 36404528
Purpose: Increased oxygen levels may enhance the radiosensitivity of brain metastases treated with stereotactic radiosurgery (SRS). This project administered hyperbaric oxygen (HBO) prior to SRS to assess feasibility, safety, and...
18.
Hong J, Quon R, Song Y, Xie T, Levy J, DAgostino E, et al.
Neurosurgery
. 2022 Oct;
92(1):186-194.
PMID: 36255216
Background: Direct cortical stimulation of the mesial frontal premotor cortex, including the supplementary motor area (SMA), is challenging in humans. Limited access to these brain regions impedes understanding of human...
19.
Chilton M, Api A, Foster R, Gerberick G, Lavelle M, Macmillan D, et al.
Regul Toxicol Pharmacol
. 2022 Jun;
133:105200.
PMID: 35662638
The Dermal Sensitisation Thresholds (DST) are Thresholds of Toxicological Concern, which can be used to justify exposure-based waiving when conducting a skin sensitisation risk assessment. This study aimed to update...
20.
Johnson C, Anger L, Benigni R, Bower D, Bringezu F, Crofton K, et al.
Comput Toxicol
. 2022 Apr;
21.
PMID: 35368849
Understanding the reliability and relevance of a toxicological assessment is important for gauging the overall confidence and communicating the degree of uncertainty related to it. The process involved in assessing...