David W Murhammer
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Explore the profile of David W Murhammer including associated specialties, affiliations and a list of published articles.
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17
Citations
63
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Recent Articles
1.
Das A, Dutta S, Sen M, Saxena A, Kumar J, Giri L, et al.
Biotechnol Bioeng
. 2020 Sep;
118(1):238-252.
PMID: 32936454
Baculoviruses have enormous potential for use as biopesticides to control insect pest populations without the adverse environmental effects posed by the widespread use of chemical pesticides. However, continuous baculovirus production...
2.
Murhammer D
Methods Mol Biol
. 2016 Jan;
1350:3-22.
PMID: 26820851
The insect cell culture/baculovirus system has three primary applications: (1) recombinant protein synthesis, (2) biopesticide synthesis, and (3) as a model system (e.g., for studying apoptosis). The fundamental techniques involved...
3.
Vajrala S, Murhammer D
Biotechnol Prog
. 2016 Jan;
32(2):465-9.
PMID: 26785218
A problem in the mass production of recombinant proteins and biopesticides using insect cell culture is CO2 accumulation. This research investigated the effect of elevated CO2 concentration on insect cell...
4.
Qiu J, Arnold M, Murhammer D
J Biotechnol
. 2014 Jan;
173:106-11.
PMID: 24452098
Near infrared spectroscopy is demonstrated as a suitable method for monitoring real time cell density and concentrations of glucose and lactate during insect cell cultivation. The utility of this approach...
5.
Giri L, Feiss M, Bonning B, Murhammer D
J Gen Virol
. 2011 Oct;
93(Pt 2):389-399.
PMID: 21994323
Accumulation of baculovirus defective interfering particle (DIP) and few polyhedra (FP) mutants is a major limitation to continuous large-scale baculovirus production in insect-cell culture. Although overcoming these mutations would result...
6.
Giri L, Li H, Sandgren D, Feiss M, Roller R, Bonning B, et al.
J Gen Virol
. 2010 Sep;
91(Pt 12):3053-64.
PMID: 20810745
Low-cost, large-scale production of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) using continuous insect cell culture is seriously hindered by the accumulation of AcMNPV mutants. Specifically, few-polyhedra (FP) mutants, with...
7.
Murhammer D
Methods Mol Biol
. 2007 Oct;
388:3-22.
PMID: 17951763
The insect cell culture/baculovirus system has three primary applications: (1) recombinant protein synthesis, (2) biopesticide synthesis, and (3) as a model system (e.g., for studying apoptosis). The fundamental techniques involved...
8.
Zhang F, Bries A, Lang S, Wang Q, Murhammer D, Weiler J, et al.
Biochim Biophys Acta
. 2004 Dec;
1739(1):43-9.
PMID: 15607116
Glycosylation, an important post-translation modification, could alter biological activity or influence the clearance rates of glycoproteins. We report here the first example of a heterozygous protein deficiency leading to metabolic...
9.
Wang Y, Oberley L, Howe D, Jarvis D, Chauhan G, Murhammer D
Appl Biochem Biotechnol
. 2004 Nov;
119(2):181-93.
PMID: 15531788
It has previously been demonstrated that baculovirus infection of the Spodoptera frugiperda Sf-9 (Sf-9) and Trichoplusia ni BTI-Tn-5B1-4 (Tn-5B1-4) insect cell lines leads to oxidative stress as measured by protein...
10.
Rhiel M, Cohen M, Arnold M, Murhammer D
Biotechnol Bioeng
. 2004 May;
86(7):852-61.
PMID: 15162462
PC-3 human prostate cancer cells have been cultivated in a rotating wall vessel in which glucose, lactate, and glutamine profiles were monitored noninvasively and in real time by near-infrared (NIR)...