David W Kubiak
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Explore the profile of David W Kubiak including associated specialties, affiliations and a list of published articles.
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40
Citations
397
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Recent Articles
1.
Tong D, Hughes M, Hu J, Pearson J, Kubiak D, Dionne B, et al.
Antimicrob Agents Chemother
. 2025 Jan;
69(2):e0104024.
PMID: 39791873
Tobramycin dosing in patients with cystic fibrosis (CF) is challenged by its high pharmacokinetic (PK) variability and narrow therapeutic window. Doses are typically individualized using two-sample log-linear regression (LLR) to...
2.
Gillett E, Aleissa M, Pearson J, Solomon D, Kubiak D, Dionne B, et al.
Open Forum Infect Dis
. 2024 Nov;
11(11):ofae600.
PMID: 39507879
Background: Current vancomycin monitoring guidelines recommend monitoring 24-hour area under the concentration-time curve (AUC) to minimum inhibitory concentration ratios for patients with serious methicillin-resistant infections. However, there are sparse data...
3.
Gohil S, Septimus E, Kleinman K, Varma N, Avery T, Heim L, et al.
JAMA
. 2024 Apr;
331(23):2007-2017.
PMID: 38639729
Importance: Pneumonia is the most common infection requiring hospitalization and is a major reason for overuse of extended-spectrum antibiotics. Despite low risk of multidrug-resistant organism (MDRO) infection, clinical uncertainty often...
4.
Gohil S, Septimus E, Kleinman K, Varma N, Avery T, Heim L, et al.
JAMA
. 2024 Apr;
331(23):2018-2028.
PMID: 38639723
Importance: Urinary tract infection (UTI) is the second most common infection leading to hospitalization and is often associated with gram-negative multidrug-resistant organisms (MDROs). Clinicians overuse extended-spectrum antibiotics although most patients...
5.
Monk M, Patel N, Elshaboury R, Kubiak D, Hammond S
Open Forum Infect Dis
. 2024 Mar;
11(3):ofae063.
PMID: 38449919
commonly causes bloodstream infections (BSIs) in neutropenic patients but infrequently results in infective endocarditis (IE) in this population. Among 210 patients with neutropenia and BSI, 55% underwent cardiac imaging. None...
6.
Little J, Coughlin C, Hsieh C, Lanza M, Huang W, Kumar A, et al.
Open Forum Infect Dis
. 2024 Mar;
11(3):ofae048.
PMID: 38434615
Background: is a ubiquitous gram-positive rod-shaped bacterium that can cause sepsis and neuroinvasive disease in patients with acute leukemia or neutropenia. Methods: A single-center retrospective review was conducted to evaluate...
7.
Assadoon M, Pearson J, Kubiak D, Kovacevic M, Dionne B
Open Forum Infect Dis
. 2022 Oct;
9(10):ofac491.
PMID: 36267260
Background: Current vancomycin guidelines recommend early and frequent area-under-the-curve monitoring in patients with obesity. Vancomycin's volume of distribution is likely altered in patients with obesity, which may result in lower...
8.
Moehring R, Yarrington M, Warren B, Lokhnygina Y, Atkinson E, Bankston A, et al.
Clin Infect Dis
. 2022 Sep;
76(3):433-442.
PMID: 36167851
Background: Sepsis guidelines recommend daily review to de-escalate or stop antibiotics in appropriate patients. This randomized, controlled trial evaluated an opt-out protocol to decrease unnecessary antibiotics in patients with suspected...
9.
Alsowaida Y, Kubiak D, Dionne B, Kovacevic M, Pearson J
Antibiotics (Basel)
. 2022 Sep;
11(9).
PMID: 36140021
Aim: To evaluate the efficiency of Bayesian modeling software and first-order pharmacokinetic (PK) equations to calculate vancomycin area under the concentration-time curve (AUC) estimations. Methods: Unblinded, crossover, quasi-experimental study at...
10.
Aleissa M, Gonzalez-Bocco I, Zekery-Saad S, Kubiak D, Zhang E, Signorelli J, et al.
Open Forum Infect Dis
. 2022 Aug;
9(8):ofac306.
PMID: 35949404
Background: Methicillin-susceptible (MSSA) is a common cause of bloodstream infection (BSI) in patients with febrile neutropenia, but treatment practices vary, and guidelines are not clear on the optimal regimen. Methods:...