David W Keizer
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Explore the profile of David W Keizer including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
478
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Recent Articles
1.
Yao S, Meikle T, Keizer D, Separovic F
J Phys Chem Lett
. 2024 Aug;
15(33):8520-8525.
PMID: 39133818
In model membrane systems, such as lipidic cubic phases (LCPs), H NMR spectra are dominated by resonances from water and lipid molecules. The measurement of translational diffusion of peptides/molecules encapsulated...
2.
Meikle T, Keizer D, Separovic F, Yao S
J Colloid Interface Sci
. 2024 Apr;
666:659-669.
PMID: 38616448
Two-dimensional NOE (nuclear Overhauser effect) NMR spectroscopy was employed to investigate the dynamic properties of water within lyotropic bicontinuous lipidic cubic phases (LCPs) formed by monoolein (MO). Experiments observed categorically...
3.
Sani M, Rajput S, Keizer D, Separovic F
Methods
. 2024 Jan;
224:10-20.
PMID: 38295893
AMPs are short, mainly cationic membrane-active peptides found in all living organism. They perform diverse roles including signaling and acting as a line of defense against bacterial infections. AMPs have...
4.
Meikle T, Keizer D, Separovic F, Yao S
BBA Adv
. 2023 Apr;
2:100062.
PMID: 37082598
Nuclear magnetic resonance (NMR) spectroscopy is well-established nowadays for the elucidation of the 3D structures of proteins and protein complexes, the evaluation of biomolecular dynamics with atomistic resolution across a...
5.
Yao S, Keizer D, Babon J, Separovic F
Eur Biophys J
. 2022 Apr;
51(3):193-204.
PMID: 35380220
Defining protein oligomeric state and/or its changes in solution is of significant interest for many biophysical studies carried out in vitro, especially when the nature of the oligomeric state is...
6.
Rajput S, Yao S, Keizer D, Sani M, Separovic F
Biophys Rev
. 2022 Mar;
14(1):67-74.
PMID: 35340611
Lipidic cubic phase (LCP) structures have been used for stabilisation and crystallisation of membrane proteins and show promising properties as drug carriers. In this mini-review, we present how NMR spectroscopy...
7.
Separovic F, Keizer D, Sani M
Front Med Technol
. 2022 Jan;
2:610203.
PMID: 35047891
Antimicrobial peptides (AMPs) have attracted attention as alternatives to classic antibiotics due to their expected limited pressure on bacterial resistance mechanisms. Yet, their modes of action, in particular , remain...
8.
Meikle T, Keizer D, Separovic F, Yao S
J Chem Phys
. 2021 Dec;
155(22):224203.
PMID: 34911323
The interpretation of molecular translational diffusion as measured by pulsed gradient spin-echo NMR (PGSE NMR) can be complicated by the presence of chemical exchange and/or dipolar cross-relaxation (including relayed cross-relaxation...
9.
Rajput S, Sani M, Keizer D, Separovic F
Biochem Soc Trans
. 2021 Jun;
49(3):1457-1465.
PMID: 34156433
Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques predominantly consisting of Aβ peptide aggregates. The amyloid plaques and soluble oligomeric species of...
10.
Meikle T, Keizer D, Babon J, Drummond C, Separovic F, Conn C, et al.
J Phys Chem B
. 2020 Nov;
125(2):571-580.
PMID: 33251799
Proton transportation in proximity to the lipid bilayer membrane surface, where chemical exchange represents a primary pathway, is of significant interest in many applications including cellular energy turnover underlying ATP...