David Van Ly
Overview
Explore the profile of David Van Ly including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
271
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0
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Recent Articles
1.
Zakarya R, Chan Y, Rutting S, Reddy K, Bozier J, Woldhuis R, et al.
Thorax
. 2021 Jan;
76(7):647-655.
PMID: 33504568
Rationale: In COPD, small airway fibrosis occurs due to increased extracellular matrix (ECM) deposition in and around the airway smooth muscle (ASM) layer. Studies of immune cells and peripheral lung...
2.
Van Ly D, Wang D, Conway R, Giblin M, Liang S, Lukeis R, et al.
Ocul Oncol Pathol
. 2021 Jan;
6(6):416-421.
PMID: 33447591
Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular...
3.
Lamm N, Read M, Nobis M, Van Ly D, Page S, Masamsetti V, et al.
Nat Cell Biol
. 2020 Dec;
22(12):1460-1470.
PMID: 33257806
Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here we reveal that nuclear F-actin participates...
4.
Ruis P, Van Ly D, Borel V, Kafer G, McCarthy A, Howell S, et al.
Nature
. 2020 Nov;
589(7840):103-109.
PMID: 33239783
Mammalian telomeres protect chromosome ends from aberrant DNA repair. TRF2, a component of the telomere-specific shelterin protein complex, facilitates end protection through sequestration of the terminal telomere repeat sequence within...
5.
Sarek G, Kotsantis P, Ruis P, Van Ly D, Margalef P, Borel V, et al.
Nature
. 2019 Nov;
575(7783):523-527.
PMID: 31723267
The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3' single-stranded telomere end can assemble into...
6.
Van Ly D, Low R, Frolich S, Bartolec T, Kafer G, Pickett H, et al.
Mol Cell
. 2018 Jul;
71(4):510-525.e6.
PMID: 30033372
Telomeres regulate DNA damage response (DDR) and DNA repair activity at chromosome ends. How telomere macromolecular structure contributes to ATM regulation and its potential dissociation from control over non-homologous end...
7.
Slatter T, Wilson M, Tang C, Campbell H, Ward V, Young V, et al.
Oncoimmunology
. 2016 May;
5(3):e1112941.
PMID: 27141366
Activated antigen-presenting cells (APC) deliver the three signals cytotoxic T cells require to differentiate into effector cells that destroy the tumor. These comprise antigen, co-stimulatory signals and cytokines. Once these...
8.
Tang F, Van Ly D, Spann K, Reading P, Burgess J, Hartl D, et al.
Respirology
. 2015 Oct;
21(1):172-9.
PMID: 26477783
Background And Objective: Respiratory viral infections are a major cause of asthma exacerbations. Neutrophils accumulate in the airways and the mechanisms that link neutrophilic inflammation, viral infections and exacerbations are...
9.
Van Ly D, Oliver B
Curr Drug Deliv
. 2014 Jun;
12(1):9-15.
PMID: 24909291
There is an enormous drive to refine therapeutic designs and delivery systems, but in this review we ask if this is always the right direction? We choose to play devil's...
10.
Van Ly D, De Pedro M, James P, Morgan L, Black J, Burgess J, et al.
Respir Res
. 2013 Nov;
14:127.
PMID: 24237854
Background: Virus-induced exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a significant health burden and occur even in those receiving the best current therapies. Rhinovirus (RV) infections are responsible for...