David V Serreze
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Explore the profile of David V Serreze including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al.
Science
. 2021 Jan;
371(6526).
PMID: 33446526
Human monogenic disorders have revealed the critical contribution of type 17 responses in mucosal fungal surveillance. We unexpectedly found that in certain settings, enhanced type 1 immunity rather than defective...
12.
Debreceni I, Chimenti M, Serreze D, Geurts A, Chen Y, Lieberman S
Int J Mol Sci
. 2020 Dec;
21(24).
PMID: 33322152
Sjögren syndrome (SS) is an immunologically complex, chronic autoimmune disease targeting lacrimal and salivary glands. Nonobese diabetic (NOD) mice spontaneously develop inflammation of lacrimal and salivary glands with histopathological features...
13.
Shapiro M, Yeh W, Longfield J, Gallagher J, Infante C, Wellford S, et al.
Front Immunol
. 2020 Oct;
11:2180.
PMID: 33013915
The costimulatory molecule CD226 is highly expressed on effector/memory T cells and natural killer cells. Costimulatory signals received by T cells can impact both central and peripheral tolerance mechanisms. Genetic...
14.
Racine J, Chapman H, Doty R, Cairns B, Hines T, Tadenev A, et al.
J Immunol
. 2020 Sep;
205(8):2026-2038.
PMID: 32938729
It has become increasingly appreciated that autoimmune responses against neuronal components play an important role in type 1 diabetes (T1D) pathogenesis. In fact, a large proportion of islet-infiltrating B lymphocytes...
15.
Ye C, Low B, Wiles M, Brusko T, Serreze D, Driver J
J Immunol
. 2020 Sep;
205(7):1763-1777.
PMID: 32868408
The CD27-CD70 costimulatory pathway is essential for the full activation of T cells, but some studies show that blocking this pathway exacerbates certain autoimmune disorders. In this study, we report...
16.
Wright J, Saunders D, Dai C, Poffenberger G, Cairns B, Serreze D, et al.
Diabetologia
. 2020 May;
63(7):1418-1423.
PMID: 32388592
Aims/hypothesis: Individuals with longstanding and recent-onset type 1 diabetes have a smaller pancreas. Since beta cells represent a very small portion of the pancreas, the loss of pancreas volume in...
17.
Foda B, Ciecko A, Serreze D, Ridgway W, Geurts A, Chen Y
J Immunol
. 2020 Apr;
204(11):2887-2899.
PMID: 32295876
CD137 modulates type 1 diabetes (T1D) progression in NOD mice. We previously showed that CD137 expression in CD4 T cells inhibits T1D, but its expression in CD8 T cells promotes...
18.
Ciecko A, Foda B, Barr J, Ramanathan S, Atkinson M, Serreze D, et al.
Cell Rep
. 2019 Dec;
29(10):3073-3086.e5.
PMID: 31801074
Human genetic studies implicate interleukin-27 (IL-27) in the pathogenesis of type 1 diabetes (T1D), but the underlying mechanisms remain largely unexplored. To further define the role of IL-27 in T1D,...
19.
Forsberg M, Foda B, Serreze D, Chen Y
Sci Rep
. 2019 Mar;
9(1):4316.
PMID: 30867509
Rodent complex trait genetic studies involving a cross between two inbred strains are usually followed by congenic mapping to refine the loci responsible for the phenotype. However, progressing from a...
20.
Sandor A, Lindsay R, Dyjack N, Whitesell J, Rios C, Bradley B, et al.
Front Immunol
. 2019 Feb;
10:99.
PMID: 30766536
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D,...