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David T Teachey

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Articles 178
Citations 11602
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Recent Articles
1.
Wang Q, Boccalatte F, Xu J, Gambi G, Nadorp B, Akter F, et al.
J Exp Med . 2025 Feb; 222(4). PMID: 39969525
While the mutational landscape across early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) and ETP-like leukemia is known, establishing a unified framework that activates stem cell genes characteristic of these tumors...
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Hughes A, Polonen P, Teachey D
Haematologica . 2025 Jan; PMID: 39781622
While outcomes for pediatric acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) have improved dramatically in recent decades, relapsed and refractory disease remain a significant therapeutic challenge. This is particularly...
4.
Hoff F, Sriraja L, Qiu Y, Jenkins G, Teachey D, Wood B, et al.
Cancers (Basel) . 2025 Jan; 16(24). PMID: 39766140
Background: The 5-year overall survival (OS) rates of T-cell lymphocytic leukemia (T-ALL) are better for children (>90%) compared to adults (~57%). The early T-cell precursor (ETP) T-ALL subtype is prognostically...
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Gupta S, Rau R, Kairalla J, Rabin K, Wang C, Angiolillo A, et al.
N Engl J Med . 2024 Dec; 392(9):875-891. PMID: 39651791
Background: B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common childhood cancer. Despite a high overall cure rate, relapsed B-cell ALL remains a leading cause of cancer-related death among...
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Xu J, Chen C, Sussman J, Yoshimura S, Vincent T, Polonen P, et al.
Nat Cancer . 2024 Nov; 6(1):102-122. PMID: 39587259
Refractoriness to initial chemotherapy and relapse after remission are the main obstacles to curing T cell acute lymphoblastic leukemia (T-ALL). While tumor heterogeneity has been implicated in treatment failure, the...
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Diorio C, Teachey D, Grupp S
Nat Rev Clin Oncol . 2024 Nov; 22(1):10-27. PMID: 39548270
Chimeric antigen receptor (CAR) T cells are revolutionizing cancer therapy, particularly for haematological malignancies, conferring durable and sometimes curative responses in patients with advanced-stage disease. The CAR T cell products...
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Newman H, Teachey D
Blood . 2024 Oct; 144(15):1545-1547. PMID: 39388162
No abstract available.
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Gallo P, Kim J, McNerney K, Diorio C, Foley C, Kagami L, et al.
J Allergy Clin Immunol . 2024 Sep; 155(2):594-604.e5. PMID: 39303891
Background: Cytokines are soluble signaling proteins that regulate inflammation and coordinate immune responses. Serum cytokine panels are increasingly used in medical practice, yet our understanding of cytokines as biomarkers for...
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Summers R, Teachey D
Blood . 2024 Aug; 144(9):924-925. PMID: 39207812
No abstract available.