David Stellwagen
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Explore the profile of David Stellwagen including associated specialties, affiliations and a list of published articles.
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38
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3522
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Recent Articles
1.
Lau D, Tobin S, Pribiag H, Nakajima S, Fisette A, Matthys D, et al.
Nat Commun
. 2024 Dec;
15(1):10652.
PMID: 39681558
α/β-hydrolase domain 6 (ABHD6) is a lipase linked to physiological functions affecting energy metabolism. Brain ABHD6 degrades 2-arachidonoylglycerol and thereby modifies cannabinoid receptor signalling. However, its functional role within mesoaccumbens...
2.
Heir R, Abbasi Z, Komal P, Altimimi H, Franquin M, Moschou D, et al.
J Neurosci
. 2024 Feb;
44(14).
PMID: 38395613
Tumor necrosis factor α (TNF) mediates homeostatic synaptic plasticity (HSP) in response to chronic activity blockade, and prior work has established that it is released from glia. Here we demonstrate...
3.
Sakai M, Yu Z, Taniguchi M, Picotin R, Oyama N, Stellwagen D, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835209
N-acetylcysteine (NAC) is an antioxidant that prevents tumor necrosis factor (TNF)-α-induced cell death, but it also acts as a pro-oxidant, promoting reactive oxygen species independent apoptosis. Although there is plausible...
4.
Chambon J, Komal P, Lewitus G, Kemp G, Valade S, Adaidi H, et al.
J Neurosci
. 2022 Dec;
43(4):672-680.
PMID: 36517241
Huntington's disease (HD) is a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin gene. Neurodegeneration first occurs in the striatum, accompanied by an elevation in inflammatory cytokines. Using...
5.
Foley K, Altimimi H, Hou H, Zhang Y, McKee C, Papasergi-Scott M, et al.
Front Synaptic Neurosci
. 2022 Oct;
14:1021832.
PMID: 36276179
Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1...
6.
Kemp G, Altimimi H, Nho Y, Heir R, Klyczek A, Stellwagen D
Mol Psychiatry
. 2022 Sep;
27(11):4474-4484.
PMID: 36104437
Acute stress triggers plasticity of forebrain synapses as well as behavioral changes. Here we reveal that Tumor Necrosis Factor α (TNF) is a required downstream mediator of the stress response...
7.
Feinberg P, Becker S, Chung L, Ferrari L, Stellwagen D, Anaclet C, et al.
J Neurosci
. 2022 Jul;
42(32):6171-6185.
PMID: 35790400
Interferon regulatory factor 8 (IRF8) is a transcription factor necessary for the maturation of microglia, as well as other peripheral immune cells. It also regulates the transition of microglia and...
8.
Manjari S, Maity S, Poornima R, Yau S, Vaishali K, Stellwagen D, et al.
Neuroscience
. 2022 Apr;
492:67-81.
PMID: 35413386
A number of studies has explored a positive correlation between low levels of serum Vitamin D (VD; cholecalciferol) and development of neurodegenerative diseases including Huntington's disease (HD). In the present...
9.
Sakai M, Yu Z, Hirayama R, Nakasato M, Kikuchi Y, Ono C, et al.
Neural Plast
. 2022 Feb;
2022:7503553.
PMID: 35222638
Major depressive disorder (MDD) is associated with repeated exposure to environmental stress. Autophagy is activated under various stress conditions that are associated with several diseases in the brain. This study...
10.
Heir R, Stellwagen D
Front Cell Neurosci
. 2020 Nov;
14:565841.
PMID: 33192311
Since it was first described almost 30 years ago, homeostatic synaptic plasticity (HSP) has been hypothesized to play a key role in maintaining neuronal circuit function in both developing and...