David S Umbaugh
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Explore the profile of David S Umbaugh including associated specialties, affiliations and a list of published articles.
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21
Citations
278
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Recent Articles
1.
Umbaugh D, Nguyen N, Curry S, Rule J, Lee W, Ramachandran A, et al.
medRxiv
. 2025 Mar;
PMID: 40034764
Background And Aims: Acetaminophen (APAP) overdose is the leading individual cause of acute liver failure (ALF) in the United States, with many patients rapidly progressing to hyperacute liver failure. While...
2.
Sanchez-Guerrero G, Umbaugh D, Smith S, Akakpo J, Jaeschke H, Ramachandran A
Toxicol Sci
. 2025 Feb;
PMID: 39985503
An overdose of acetaminophen (APAP) is the leading cause of drug-induced hepatotoxicity and acute liver failure (ALF) in the United States. It is established that the predominant mode of hepatocyte...
3.
Sanchez-Guerrero G, Umbaugh D, Ramachandran A, Artigues A, Jaeschke H, Ramachandran A
Livers
. 2024 Jul;
4(1):15-30.
PMID: 39007013
The adenosine A2B receptor (A2BAR) is a member of a family of G-protein coupled receptors (GPCRs), which has a low affinity for adenosine and is now implicated in several pathophysiological...
4.
Umbaugh D, Nguyen N, Smith S, Ramachandran A, Jaeschke H
Toxicology
. 2024 Apr;
504:153804.
PMID: 38614205
Fifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine...
5.
Umbaugh D, Jaeschke H
Expert Rev Clin Pharmacol
. 2024 Jan;
17(2):143-155.
PMID: 38217408
Introduction: Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury and can cause a rapid progression to acute liver failure (ALF). Therefore, the identification of prognostic biomarkers to...
6.
Umbaugh D, Nguyen N, Curry S, Rule J, Lee W, Ramachandran A, et al.
Hepatology
. 2023 Nov;
79(6):1352-1364.
PMID: 37910653
Background And Aims: Patients with acetaminophen-induced acute liver failure are more likely to die while on the liver transplant waiting list than those with other causes of acute liver failure....
7.
Nguyen N, Umbaugh D, Smith S, Adelusi O, Sanchez-Guerrero G, Ramachandran A, et al.
Arch Toxicol
. 2023 Mar;
97(5):1397-1412.
PMID: 36928416
Acetaminophen (APAP) overdose is the leading cause of acute liver failure in western countries. APAP can cause extensive hepatocellular necrosis, which triggers an inflammatory response involving neutrophil and monocyte recruitment....
8.
Jaeschke H, Umbaugh D, Ramachandran A
Livers
. 2023 Jan;
2(4):425-435.
PMID: 36588962
Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in response to an overdose. Understanding the mechanisms of APAP-induced cell death is critical...
9.
Umbaugh D, Maciejewski J, Wooten J, Guilford B
Front Physiol
. 2022 Sep;
13:891550.
PMID: 36082224
Peripheral neuropathy (PN), a debilitating complication of diabetes, is associated with obesity and the metabolic syndrome in nondiabetic individuals. Evidence indicates that a high fat diet can induce signs of...
10.
Umbaugh D, Soder R, Nguyen N, Adelusi O, Robarts D, Woolbright B, et al.
Arch Toxicol
. 2022 Sep;
96(12):3315-3329.
PMID: 36057886
The persistence of hepatotoxicity induced by N-acetyl-para-aminophenol (Acetaminophen or Paracetamol, abbreviated as APAP) as the most common cause of acute liver failure in the United States, despite the availability of...