David S Leake
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Explore the profile of David S Leake including associated specialties, affiliations and a list of published articles.
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31
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578
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Recent Articles
1.
Shirey K, Romerio A, Shaik M, Leake D, Palmer C, Skupinska N, et al.
Innate Immun
. 2025 Mar;
31:17534259241313201.
PMID: 40033742
Background: Acute Lung Injuries (ALI) are a severe consequence of influenza-induced cytokine storm that can cause respiratory failure and death. It has been demonstrated that Toll-like Receptor 4 (TLR4) is...
2.
Alboaklah H, McNeish A, Leake D
Free Radic Res
. 2024 Sep;
58(8-9):509-516.
PMID: 39268686
Endothelial dysfunction is a risk factor for atherosclerosis and includes impaired endothelium-dependent vasodilatation. We have shown previously that low density lipoprotein (LDL) can be oxidized by iron in the lysosomes...
3.
Poston R, Chughtai J, Ujkaj D, Louis H, Leake D, Cooper D
Biomedicines
. 2022 Dec;
10(12).
PMID: 36551839
Atherosclerosis, the major cause of vascular disease, is an inflammatory process driven by entry of blood monocytes into the arterial wall. LDL normally enters the wall, and stimulates monocyte adhesion...
4.
Ojo O, Leake D
Free Radic Res
. 2022 Oct;
56(5-6):436-446.
PMID: 36217887
We have previously demonstrated that low-density lipoprotein (LDL) can be oxidized by iron in the lysosomes of macrophages. Some of the iron content of lysosomes might be delivered through autophagy...
5.
Ahmad F, Mitchell R, Houben T, Palo A, Yadati T, Parnell A, et al.
J Am Heart Assoc
. 2021 Sep;
10(18):e017524.
PMID: 34493066
Background We have shown previously that low-density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in...
6.
Ojo O, Leake D
Free Radic Res
. 2021 Aug;
55(5):525-534.
PMID: 34396869
Low density lipoprotein (LDL) might be oxidized by iron in the lysosomes of macrophages in atherosclerotic lesions. We have shown previously that the iron-storage proteinferritin can oxidize LDL at lysosomal...
7.
Alboaklah H, Leake D
Free Radic Res
. 2020 Sep;
54(8-9):574-584.
PMID: 32938237
Many cholesterol-laden foam cells in atherosclerotic lesions are macrophages and much of their cholesterol is present in their lysosomes and derived from low density lipoprotein (LDL). LDL oxidation has been...
8.
Wen Y, Ahmad F, Mohri Z, Weinberg P, Leake D
Atherosclerosis
. 2019 Oct;
291:9-18.
PMID: 31629988
Background And Aims: We have shown previously that low density lipoprotein (LDL) aggregated by vortexing is internalised by macrophages and oxidised by iron in lysosomes to form the advanced lipid/protein...
9.
Ahmad F, Leake D
J Lipid Res
. 2018 Nov;
60(1):98-110.
PMID: 30397186
We have shown that aggregated LDL is internalized by macrophages and oxidized in lysosomes by redox-active iron. We have now investigated to determine whether the lysosomal oxidation of LDL impairs...
10.
Ojo O, Leake D
Chem Phys Lipids
. 2018 Oct;
217:51-57.
PMID: 30287220
Oxidation of low density lipoprotein (LDL) has been proposed to be involved in the pathogenesis of atherosclerosis. We have previously shown that LDL can be oxidised by iron in lysosomes....