David S Kliger
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Explore the profile of David S Kliger including associated specialties, affiliations and a list of published articles.
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51
Citations
368
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Recent Articles
1.
Szundi I, Kliger D
Biophys J
. 2024 May;
123(12):1735-1750.
PMID: 38762755
The light-gated anion channelrhodopsin GtACR1 is an important optogenetic tool for neuronal silencing. Its photochemistry, including its photointermediates, is poorly understood. The current mechanistic view presumes BR-like kinetics and assigns...
2.
Szundi I, Kliger D
Biophys J
. 2024 Mar;
123(8):940-946.
PMID: 38462839
Anion channelrhodopsin GtACR1 is a powerful optogenetic tool to inhibit nerve activity. Its kinetic mechanism was interpreted in terms of the bacteriorhodopsin photocycle, and the L intermediate was assigned to...
3.
Schleissner P, Szundi I, Chen E, Li H, Spudich J, Kliger D
Biophys J
. 2023 Sep;
122(20):4091-4103.
PMID: 37749886
The most effective tested optogenetic tools available for neuronal silencing are the light-gated anion channel proteins found in the cryptophyte alga Guillardia theta (GtACRs). Molecular mechanisms of GtACRs, including the...
4.
Szundi I, Pitch S, Chen E, Farrens D, Kliger D
Biophys J
. 2021 Sep;
120(20):4337-4348.
PMID: 34509506
Styrene-maleic acid (SMA) copolymers solubilize biological membranes to form lipid nanoparticles (SMALPs) that contain membrane proteins surrounded by native lipids, thus enabling the use of a variety of biophysical techniques...
5.
Pitch S, Yao W, Szundi I, Fay J, Chen E, Shumate A, et al.
Biophys J
. 2021 May;
120(16):3508-3515.
PMID: 34022241
Membrane proteins often require solubilization to study their structure or define the mechanisms underlying their function. In this study, the functional properties of the membrane protein rhodopsin in its native...
6.
Clinger J, Chen E, Kliger D, Phillips Jr G
J Phys Chem B
. 2020 Dec;
125(1):202-210.
PMID: 33355472
The bilin-containing photoreceptor TePixJ, a member of the cyanobacteriochrome (CBCR) family of phytochromes, switches between blue-light-absorbing and green-light-absorbing states in order to drive phototaxis in . Its photoswitching process involves...
7.
Fried S, Lewis J, Szundi I, Martinez-Mayorga K, Mahalingam M, Vogel R, et al.
Biophys J
. 2020 Nov;
120(3):440-452.
PMID: 33217383
G-protein-coupled receptors (GPCRs) comprise the largest and most pharmacologically targeted membrane protein family. Here, we used the visual receptor rhodopsin as an archetype for understanding membrane lipid influences on conformational...
8.
Xu K, Vickers E, Luo B, Allen A, Chen E, Roseman G, et al.
J Phys Chem Lett
. 2020 Jan;
11(3):1162-1169.
PMID: 31967831
Mn-doped CsPbBr perovskite magic sized clusters (PMSCs) are synthesized for the first time using benzoic acid and benzylamine as passivating ligands and MnCl·4HO and MnBr as the Mn dopant sources...
9.
Kim Y, Puhl 3rd H, Chen E, Taumoefolau G, Nguyen T, Kliger D, et al.
Biophys J
. 2019 May;
116(10):1918-1930.
PMID: 31060812
Fluorescent proteins (FPs) have revolutionized cell biology by allowing genetic tagging of specific proteins inside living cells. In conjunction with Förster's resonance energy transfer (FRET) measurements, FP-tagged proteins can be...
10.
Chen E, Esquerra R, Melendez P, Chandrasekaran S, Kliger D
J Phys Chem B
. 2018 Aug;
122(49):11381-11389.
PMID: 30118225
A protein's folding or function depends on its mobility through the viscous environment that is defined by the presence of macromolecules throughout the cell. The relevant parameter for this mobility...